Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet.
Metabolic regulation of T cells in the tumor microenvironment by nutrient availability and diet.
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通过营养可用性和饮食对肿瘤微环境中T细胞的代谢调节。
DOI：
10.1016/j.smim.2021.101485
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发表时间：
2021-03
影响因子：
7.8
通讯作者：
Kaech SM
中科院分区：
文献类型：
--
作者：
Zhao S;Peralta RM;Avina-Ochoa N;Delgoffe GM;Kaech SM
免疫疗法的最新进展，如免疫检查点阻断（ICB）和嵌合抗原受体T细胞（CAR-T）治疗癌症的能力令人兴奋，因为它们能够在多种癌症中产生持久的、潜在的治愈性反应。这些发现证实了免疫系统能够消灭肿瘤，并使我们对肿瘤与免疫系统相互作用和逃避免疫系统破坏的机制有了更好的理解，尽管仍然不完整。鉴于T细胞在免疫治疗中的核心作用，阐明控制肿瘤中T细胞功能的细胞内在和外在因素将促进免疫疗法的发展，从而在更多的患者中建立持久的反应。其中一个因素是代谢，这是一组基本的细胞过程，不仅维持细胞的生存和增殖，而且还作为细胞解释其局部环境的手段。营养感知对T细胞至关重要，T细胞必须渗透到代谢具有挑战性的肿瘤微环境中，并在这些恶劣条件下扩张以消除癌细胞。在这里，我们介绍了T细胞耗竭与细胞代谢的关系，随后讨论了肿瘤和机体水平上与T细胞代谢和功能有关的营养可用性，为抗肿瘤免疫反应中代谢的研究和靶向提供理论依据。
Recent advances in immunotherapies such as immune checkpoint blockade (ICB) and chimeric antigen receptor T cells (CAR-T) for the treatment of cancer have generated excitement over their ability to yield durable, and potentially curative, responses in a multitude of cancers. These findings have established that the immune system is capable of eliminating tumors and led us to a better, albeit still incomplete, understanding of the mechanisms by which tumors interact with and evade destruction by the immune system. Given the central role of T cells in immunotherapy, elucidating the cell intrinsic and extrinsic factors that govern T cell function in tumors will facilitate the development of immunotherapies that establish durable responses in a greater number of patients. One such factor is metabolism, a set of fundamental cellular processes that not only sustains cell survival and proliferation, but also serves as a means for cells to interpret their local environment. Nutrient sensing is critical for T cells that must infiltrate into a metabolically challenging tumor microenvironment and expand under these harsh conditions to eliminate cancerous cells. Here we introduce T cell exhaustion with respect to cellular metabolism, followed by a discussion of nutrient availability at the tumor and organismal level in relation to T cell metabolism and function to provide rationale for the study and targeting of metabolism in anti-tumor immune responses.
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影响因子：
11.2
作者：
Barsoum, Ivraym B.;Smallwood, Chelsea A.;Graham, Charles H.
通讯作者：
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影响因子：
11.4
作者：
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DEMEYTS, P
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32.4
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通讯作者：
Zelenay S
影响因子：
4.6
作者：
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通讯作者：
Flaveny, Colin A.