Role of mineralization inhibitors in the regulation of hard tissue biomineralization: relevance to initial enamel formation and maturation.
Role of mineralization inhibitors in the regulation of hard tissue biomineralization: relevance to initial enamel formation and maturation.
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DOI：
10.3389/fphys.2014.00339
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发表时间：
2014
影响因子：
4
通讯作者：
Yamazaki H
中科院分区：
文献类型：
--
作者：
Margolis HC;Kwak SY;Yamazaki H
脊椎动物矿化组织，即，牙釉质、牙本质、牙骨质和骨具有独特的分级结构和化学组成。虽然这些组织类似地由结晶钙磷灰石矿物相和蛋白质组分组成，但它们在晶体大小和形状、微量矿物离子的水平和分布、存在的蛋白质的性质以及它们的矿物和蛋白质组分的相对比例方面不同。尽管有明显的差异，矿化组织类似地由高度协调的细胞外过程衍生，所述细胞外过程涉及基质蛋白、蛋白酶和矿物离子通量，所述矿物离子通量共同调节形成矿物晶体的成核、生长和组织。然而，自然界提供了多种方法来控制发育中矿化组织中矿物沉积物的发生、速率、位置和组织。虽然我们的知识是相当有限的，在这些领域中的一些，最近的证据表明，硬组织的形成，在一定程度上，通过调节抑制矿化过程的特定分子的控制。本文论述了矿化抑制剂在生物矿化调节中的作用，重点是当前研究结果与釉质形成过程的相关性。矿化抑制剂还可用于维持磷酸钙沉淀的驱动力并防止不需要的矿化。最近的证据表明，天然磷酸化釉原蛋白有能力通过稳定无定形磷酸钙前体相来防止矿化，如在体外和发育中的牙齿中所观察到的。基于目前的研究结果，作者提出，最初形成的无定形矿物沉积物的釉质晶体的转化是一个积极的过程与釉原蛋白的酶加工。这样的处理可以用于控制初始釉质晶体形成和随后的成熟。
Vertebrate mineralized tissues, i.e., enamel, dentin, cementum, and bone, have unique hierarchical structures and chemical compositions. Although these tissues are similarly comprised of a crystalline calcium apatite mineral phase and a protein component, they differ with respect to crystal size and shape, level and distribution of trace mineral ions, the nature of the proteins present, and their relative proportions of mineral and protein components. Despite apparent differences, mineralized tissues are similarly derived by highly concerted extracellular processes involving matrix proteins, proteases, and mineral ion fluxes that collectively regulate the nucleation, growth and organization of forming mineral crystals. Nature, however, provides multiple ways to control the onset, rate, location, and organization of mineral deposits in developing mineralized tissues. Although our knowledge is quite limited in some of these areas, recent evidence suggests that hard tissue formation is, in part, controlled through the regulation of specific molecules that inhibit the mineralization process. This paper addresses the role of mineralization inhibitors in the regulation of biological mineralization with emphasis on the relevance of current findings to the process of amelogenesis. Mineralization inhibitors can also serve to maintain driving forces for calcium phosphate precipitation and prevent unwanted mineralization. Recent evidence shows that native phosphorylated amelogenins have the capacity to prevent mineralization through the stabilization of an amorphous calcium phosphate precursor phase, as observed in vitro and in developing teeth. Based on present findings, the authors propose that the transformation of initially formed amorphous mineral deposits to enamel crystals is an active process associated with the enzymatic processing of amelogenins. Such processing may serve to control both initial enamel crystal formation and subsequent maturation.
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影响因子：
3
作者：
Fang, Ping-An;Margolis, Henry C.;Conway, James F.;Simmer, James P.;Beniash, Elia
通讯作者：
Beniash, Elia
影响因子：
3.8
作者：
Deshpande, Atul S.;Beniash, Elia
通讯作者：
Beniash, Elia
影响因子：
2.9
作者：
FUREDIMILHOFER, H;MORADIANOLDAK, J;ADDADI, L
通讯作者：
ADDADI, L
DOI：
10.1007/bf02058658
发表时间：
1969-01-01
期刊：
CALCIFIED TISSUE RESEARCH
影响因子：
--
作者：
FRANCIS, MD
通讯作者：
FRANCIS, MD
DOI：
10.1098/rspb.1997.0066
发表时间：
1997-03-22
影响因子：
4.7
作者：
Beniash, E;Aizenberg, J;Weiner, S
通讯作者：
Weiner, S