Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle.
Functions of Osteocalcin in Bone, Pancreas, Testis, and Muscle.
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骨钙素在骨，胰腺，睾丸和肌肉中的功能。
DOI：
10.3390/ijms21207513
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发表时间：
2020-10-12
影响因子：
5.6
通讯作者：
Komori T
中科院分区：
文献类型：
--
作者：
Komori T
骨钙素（Ocn），这是专门由成骨细胞产生，是最丰富的非胶原蛋白在骨，被证明是抑制骨形成和功能作为一种激素，它调节葡萄糖代谢在胰腺，睾丸中的睾酮合成，和肌肉质量，基于表型的Ocn−/−小鼠由Karsenty的小组。最近，Ocn−/−小鼠是由两组独立产生的。骨强度由骨的数量和质量决定。新的Ocn−/−小鼠表明，Ocn不参与骨形成和骨量的调节，但Ocn通过将生物磷灰石（BAp）平行于胶原纤维排列来调节骨质量。此外，葡萄糖代谢、睾酮合成和精子发生以及肌肉质量在新的Ocn−/−小鼠中是正常的。因此，Ocn的功能是将BAp的生长取向平行于胶原纤维进行调整，这对于骨强度向长骨的加载方向是重要的。然而，OCN在胰腺、睾丸和肌肉中不起激素的作用。临床上，血清Ocn是骨形成的标志物，运动增加骨形成，改善葡萄糖代谢，使Ocn与葡萄糖代谢联系起来。
Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant non-collagenous protein in bone, was demonstrated to inhibit bone formation and function as a hormone, which regulates glucose metabolism in the pancreas, testosterone synthesis in the testis, and muscle mass, based on the phenotype of Ocn−/− mice by Karsenty’s group. Recently, Ocn−/− mice were newly generated by two groups independently. Bone strength is determined by bone quantity and quality. The new Ocn−/− mice revealed that Ocn is not involved in the regulation of bone formation and bone quantity, but that Ocn regulates bone quality by aligning biological apatite (BAp) parallel to the collagen fibrils. Moreover, glucose metabolism, testosterone synthesis and spermatogenesis, and muscle mass were normal in the new Ocn−/− mice. Thus, the function of Ocn is the adjustment of growth orientation of BAp parallel to the collagen fibrils, which is important for bone strength to the loading direction of the long bone. However, Ocn does not play a role as a hormone in the pancreas, testis, and muscle. Clinically, serum Ocn is a marker for bone formation, and exercise increases bone formation and improves glucose metabolism, making a connection between Ocn and glucose metabolism.
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影响因子：
2.9
作者：
Adhami MD;Rashid H;Chen H;Javed A
通讯作者：
Javed A
影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
在四种常用的近交小鼠菌株中的体内葡萄糖代谢。
影响因子：
7.7
作者：
Berglund, Eric D.;Li, Candice Y.;Poffenberger, Greg;Ayala, Julio E.;Fueger, Patrick T.;Willis, Shannon E.;Jewell, Marybeth M.;Powers, Alvin C.;Wasserman, David H.
通讯作者：
Wasserman, David H.
影响因子：
5.2
作者：
Bailey S;Karsenty G;Gundberg C;Vashishth D
通讯作者：
Vashishth D
影响因子：
29
作者：
Berger, Julian Meyer;Singh, Parminder;Karsenty, Gerard
通讯作者：
Karsenty, Gerard