Osteocalcin and osteopontin influence bone morphology and mechanical properties.
Osteocalcin and osteopontin influence bone morphology and mechanical properties.
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DOI：
10.1111/nyas.13470
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发表时间：
2017-12
影响因子：
5.2
通讯作者：
Vashishth D
中科院分区：
文献类型：
--
作者：
Bailey S;Karsenty G;Gundberg C;Vashishth D
骨钙素（OC）和骨桥蛋白（OPN）是参与骨基质组织和沉积的主要非胶原蛋白（ncp）。尽管如此，目前尚不清楚OC和OPN是否会改变骨形态，从而影响骨折抵抗能力。本研究的目的是确定骨皮质的大小、形状和力学性能的OC和OPN的作用。我们的研究结果表明Oc−/−和Opn−/−小鼠在骨形态方面与野生型（WT）没有差异（P < 0.01）。与WT、Oc−/−和Opn−/−组相比，缺乏两种ncp （Oc−/−Opn−/−）的小鼠骨骼更短，皮质更厚，皮质面积更大（P < 0.05），这表明ncp在骨形态的决定中具有协同作用。各组间最大弯曲载荷差异显著（P = 0.024），而组织矿物质密度（TMD）或刚度和强度测量值无差异（P < 0.01）。我们得出结论，从骨基质中去除OC和OPN在结构水平上诱导形态适应以维持骨强度。
Osteocalcin (OC) and osteopontin (OPN) are major non-collagenous proteins (NCPs) involved in bone matrix organization and deposition. In spite of this, it is currently unknown whether OC and OPN alter bone morphology and consequently affect bone fracture resistance. The goal of this study is to establish the role of OC and OPN in the determination of cortical bone size, shape, and mechanical properties. Our results show that Oc−/− and Opn−/− mice were no different from each other or wild type (WT) with respect to bone morphology (P > 0.1). Bones from mice lacking both NCPs (Oc−/− Opn−/−) were shorter with thicker cortices and larger cortical areas compared to the WT, Oc−/−, and Opn−/− groups (P < 0.05), suggesting a synergistic role for NCPs in the determination of bone morphology. Maximum bending load was significantly different among the groups (P = 0.024), while tissue mineral density (TMD) or measures of stiffness and strength were not different (P > 0.1). We conclude that the removal of both OC and OPN from bone matrix induces morphological adaptation at the structural level to maintain bone strength.
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影响因子：
2.8
作者：
Ural, Ani;Vashishth, Deepak
通讯作者：
Vashishth, Deepak
影响因子：
--
作者：
FROST, HM
通讯作者：
FROST, HM
影响因子：
4.3
作者：
Sroga, Grazyna E.;Vashishth, Deepak
通讯作者：
Vashishth, Deepak
影响因子：
4.2
作者：
Willinghamm, Mark D.;Brodt, Michael D.;Silva, Matthew J.
通讯作者：
Silva, Matthew J.
影响因子：
64.8
作者：
Ducy, P;Desbois, C;Karsenty, G
通讯作者：
Karsenty, G