The corpus callosum and the visual cortex: plasticity is a game for two.
The corpus callosum and the visual cortex: plasticity is a game for two.
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DOI：
10.1155/2012/838672
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发表时间：
2012
影响因子：
3.1
通讯作者：
Caleo M
中科院分区：
文献类型：
--
作者：
Pietrasanta M;Restani L;Caleo M
在一生中，经历塑造并选择了最合适的大脑功能连接，以适应不断变化的环境。研究经验依赖可塑性的理想系统是视觉皮层，因为视觉经验很容易被操纵。在本文中，我们关注的是在视觉皮层的经验依赖可塑性的半球间，跨胼胝体投影的作用。我们回顾数据显示，感官体验的剥夺可以改变胼胝体纤维的形态，从而改变两个半球之间的通信。更重要的是，在早期关键时期对胼胝体输入活动的操纵改变了视觉皮层功能特性的发育成熟，并改变了其响应经验的重塑能力。我们还讨论了大鼠视觉皮层的最新数据，表明胼胝体在皮层神经元的双眼视中起作用，并参与了早期单眼缝合（单眼剥夺）后眼睛偏好的可塑性转移。因此，经验可以改变胼胝体的精细连通性，胼胝体连接是经验介导视觉皮层功能成熟和可塑性重排的主要途径。
Throughout life, experience shapes and selects the most appropriate brain functional connectivity to adapt to a changing environment. An ideal system to study experience-dependent plasticity is the visual cortex, because visual experience can be easily manipulated. In this paper, we focus on the role of interhemispheric, transcallosal projections in experience-dependent plasticity of the visual cortex. We review data showing that deprivation of sensory experience can modify the morphology of callosal fibres, thus altering the communication between the two hemispheres. More importantly, manipulation of callosal input activity during an early critical period alters developmental maturation of functional properties in visual cortex and modifies its ability to remodel in response to experience. We also discuss recent data in rat visual cortex, demonstrating that the corpus callosum plays a role in binocularity of cortical neurons and is involved in the plastic shift of eye preference that follows a period of monocular eyelid suture (monocular deprivation) in early age. Thus, experience can modify the fine connectivity of the corpus callosum, and callosal connections represent a major pathway through which experience can mediate functional maturation and plastic rearrangements in the visual cortex.
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DOI：
10.1073/pnas.0500003102
发表时间：
2005-05-17
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.0907655106
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.4
作者：
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