Characterization of two crystal forms of neutrophil cationic protein NP2, a naturally occurring broad-spectrum antimicrobial agent from leukocytes.

Characterization of two crystal forms of neutrophil cationic protein NP2, a naturally occurring broad-spectrum antimicrobial agent from leukocytes.
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中性粒细胞阳离子蛋白 NP2 的两种晶型的表征,NP2 是一种来自白细胞的天然广谱抗菌剂。

DOI:
10.1016/0022-2836(84)90252-3
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发表时间:
1984
影响因子:
5.6
通讯作者:
Selsted,ME
Selsted,ME
中科院分区:
生物学2区
文献类型:
--
作者:
Westbrook,EM;Lehrer,RI;Selsted,ME

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中性粒细胞阳离子蛋白NP 2的一种六方晶型(P6 3 2 2,a= B= 34.0 A β,c= 113.5 A β)和一种单斜晶型(P2 1,a= 37.1 A β,B= 32.2 A β,c= 32.4 A β,β= 110°)已被鉴定。单斜晶型,每个不对称单元含有两个促进剂(MR = 3844),衍射到至少1.8 nm,适合于高分辨率结构研究。
A hexagonal crystal form (P6 3 22, a= b= 34.0 A ̊, c= 113.5 A ̊) and a monoclinic form (P2 1, a= 37.1 A ̊, b= 32.2 A ̊, c= 32.4 A ̊, β= 110°) of neutrophil cationic protein NP2, isolated from rabbit leukocytes, have been characterized. The monoclinic form, containing two promoters (M r= 3844) per asymmetric unit, diffracts to at least 1.8 Å and is suitable for high-resolution structural studies.
哺乳动物粒细胞的杀菌成分对新型隐球菌具有活性。
DOI: 10.1093/infdis/136.1.96
发表时间: 1977
期刊: The Journal of infectious diseases
影响因子: --
作者:
R. Lehrer;K. M. Ladra
通讯作者: K. M. Ladra
DOI: 10.1016/s0021-9258(17)43888-9
发表时间: 1983-12
期刊: The Journal of biological chemistry
影响因子: --
作者:
M. Selsted;D. Brown;R. Delange;R. Lehrer
通讯作者: M. Selsted;D. Brown;R. Delange;R. Lehrer