A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.
A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.
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DOI：
10.3389/fmicb.2016.01374
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发表时间：
2016
影响因子：
5.2
通讯作者：
Ceccarelli D
中科院分区：
文献类型：
--
作者：
Liakopoulos A;Mevius D;Ceccarelli D
β-内酰胺酶是肠杆菌科成员对β-内酰胺产生耐药性的主要原因。 SHV 酶出现在肠杆菌科细菌中，在二十世纪最后几十年引起医疗保健感染，现在在人类、动物和环境的不同流行病学环境中的分离株中观察到它们。 SHV β-内酰胺酶可能起源于肺炎克雷伯菌的染色体青霉素酶，目前包含大量等位基因变体，包括超广谱 β-内酰胺酶 (ESBL)、非 ESBL 和一些未分类的变体。由于氨基酸变化改变了 β-内酰胺酶活性位点周围的构型，SHV 酶已从窄谱水解活性进化为宽谱水解活性，包括单菌酰胺类和碳青霉烯类。 SHV-ESBL 通常由可自我传播的质粒编码，这些质粒经常携带对其他药物类别的抗性基因，并且已在世界范围内的几种肠杆菌科细菌中广泛传播，这强调了其临床意义。
β-lactamases are the primary cause of resistance to β-lactams among members of the family Enterobacteriaceae. SHV enzymes have emerged in Enterobacteriaceae causing infections in health care in the last decades of the Twentieth century, and they are now observed in isolates in different epidemiological settings both in human, animal and the environment. Likely originated from a chromosomal penicillinase of Klebsiella pneumoniae, SHV β-lactamases currently encompass a large number of allelic variants including extended-spectrum β-lactamases (ESBL), non-ESBL and several not classified variants. SHV enzymes have evolved from a narrow- to an extended-spectrum of hydrolyzing activity, including monobactams and carbapenems, as a result of amino acid changes that altered the configuration around the active site of the β -lactamases. SHV-ESBLs are usually encoded by self-transmissible plasmids that frequently carry resistance genes to other drug classes and have become widespread throughout the world in several Enterobacteriaceae, emphasizing their clinical significance.
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影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
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