Modeling Endoleaks and Collateral Reperfusion following Endovascular AAA Exclusion
Modeling Endoleaks and Collateral Reperfusion following Endovascular AAA Exclusion
复制标题
血管内 AAA 排除后的内漏和侧支再灌注建模
DOI：
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发表时间：
2003
影响因子：
2.6
通讯作者：
P. Harris
中科院分区：
文献类型：
--
作者：
C. K. Chong;T. How;G. Gilling;P. Harris
目的：旨在研究在压力和流量生理条件下维持的腹主动脉瘤（AAA）真人大小硅橡胶模型内覆膜支架部署对腔内压力的影响。方法：在AAA模型中部署市售分叉器械（聚酯织物预浸有明胶）。泵系统产生生理流量。使用压力传感器同时测量平均和脉搏主动脉压和动脉内压。为了模拟I型内漏，在主动脉壁和近端锚定部位的覆膜支架之间放置塑料管。通过设定流入和流出压力以及灌注速率的侧支模拟II型内漏。通过从移植物织物中去除明胶复制IV型内漏。结果：在无内漏的情况下，涂层覆膜支架将平均和脉搏囊压降低至可忽略值。当存在I型内漏时，平均囊压达到与平均主动脉压相似的值。当存在因II型内漏导致的通过囊的净流量时，平均囊压是入口压力的函数，而囊内的脉压取决于入口和出口压力。随着灌注率的增加，平均囊压和脉搏囊压均下降。当没有流出时，平均囊压与平均主动脉压相似。在存在I型和II型内漏的情况下，当净灌注率较低时，平均囊压达到平均主动脉压。结论：体外研究有助于了解不同类型内漏（单独和组合）对主动脉覆膜支架展开后腔内压力的影响。
Purpose: To investigate the effect on intrasac pressure of stent-graft deployment within a life-size silicone rubber model of an abdominal aortic aneurysm (AAA) maintained under physiological conditions of pressure and flow. Methods: A commercial bifurcated device with the polyester fabric preclotted with gelatin was deployed in the AAA model. A pump system generated physiological flow. Mean and pulse aortic and intrasac pressures were measured simultaneously using pressure transducers. To simulate a type I endoleak, plastic tubing was placed between the aortic wall and the stent-graft at the proximal anchoring site. Type II endoleak was simulated by means of side branches with set inflow and outflow pressures and perfusion rates. Type IV endoleak was replicated by removal of gelatin from the graft fabric. Results: With no endoleak, the coated graft reduced the mean and pulse sac pressures to negligible values. When a type I endoleak was present, mean sac pressure reached a value similar to mean aortic pressure. When net flow through the sac due to a type II endoleak was present, mean sac pressure was a function of the inlet pressure, while pulse pressure in the sac was dependent on both inlet and outlet pressures. As perfusion rates increased, both mean and pulse sac pressures decreased. When there was no outflow, mean sac pressure was similar to mean aortic pressure. In the presence of both type I and type II endoleaks, mean sac pressure reached mean aortic pressure when the net perfusion rate was low. Conclusions: In vitro studies are useful in gaining an understanding of the impact of different types of endoleaks, in isolation and in combination, on intrasac pressure after aortic stent-graft deployment.
慢性动脉瘤内压力测量：评估血管内主动脉瘤排除有效性的实验方法。
影响因子：
4.3
作者：
Sanchez,LA;Faries,PL;Marin,ML;Ohki,T;Parsons,RE;Marty,B;Soeiro,D;Olivieri,S;Veith,FJ
通讯作者：
Veith,FJ