Integration of syntactic and semantic properties of the DNA code reveals chromosomes as thermodynamic machines converting energy into information
Integration of syntactic and semantic properties of the DNA code reveals chromosomes as thermodynamic machines converting energy into information
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DNA 代码的句法和语义特性的整合揭示了染色体作为将能量转化为信息的热力学机器
DOI：
10.1007/s00018-013-1394-1
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发表时间：
2013
影响因子：
8
通讯作者：
A. Travers
中科院分区：
文献类型：
--
作者：
G. Muskhelishvili;A. Travers
理解遗传调控是一个至关重要的问题。最近的研究越来越清楚地表明，尽管细胞遗传调控系统包含了参与许多相互作用的多个不同的元件，但核心问题是DNA分子作为信息载体的真正功能。令人信服的证据表明，DNA除了线性遗传密码的数字信息（语义）外，还编码同样重要的连续或模拟信息，这些信息指定了聚合物的结构动力学和构型（语法）。这两种DNA信息类型在一级序列组织中内在地耦合，并且这种耦合与遗传功能的调节直接相关。在这篇评论中，我们强调的关键需要整体整合的DNA信息作为理解的遗传调控系统的组织复杂性的先决条件。
Understanding genetic regulation is a problem of fundamental importance. Recent studies have made it increasingly evident that, whereas the cellular genetic regulation system embodies multiple disparate elements engaged in numerous interactions, the central issue is the genuine function of the DNA molecule as information carrier. Compelling evidence suggests that the DNA, in addition to the digital information of the linear genetic code (the semantics), encodes equally important continuous, or analog, information that specifies the structural dynamics and configuration (the syntax) of the polymer. These two DNA information types are intrinsically coupled in the primary sequence organisation, and this coupling is directly relevant to regulation of the genetic function. In this review, we emphasise the critical need of holistic integration of the DNA information as a prerequisite for understanding the organisational complexity of the genetic regulation system.
影响因子：
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作者：
Patrick Sobetzko;M. Glinkowska;A. Travers;G. Muskhelishvili
通讯作者：
Patrick Sobetzko;M. Glinkowska;A. Travers;G. Muskhelishvili
DOI：
10.1073/pnas.0508032102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Kar, S;Edgar, R;Adhya, S
通讯作者：
Adhya, S