Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
复制标题
海马变性可区分弥漫性路易体病 (DLBD) 和阿尔茨海默病
作者：
D. Dickson;D. Ruan;H. Crystal;M. Mark;P. Davies;Y. Kress;S. Yen
免疫细胞化学与抗体的泛素是目前最敏感的方法检测皮质路易体，这是一个必要条件的诊断弥漫性路易体病（DLBD），越来越多的认可形式的原发性退行性痴呆。在系统的应用泛素免疫细胞化学的控制对象和患者的广泛的神经退行性疾病的海马切片，我们注意到经常发生的泛素免疫反应神经突在CA 2 -3区DLBD。这些神经突起的性质进行了研究，在DLBD，阿尔茨海默病（AD），正常老年人，帕金森病（PD）的免疫细胞化学。虽然神经突的数量因病例而异，但它们几乎总是在DLBD中检测到，而不是在正常，AD或PD大脑中。双重免疫标记的研究与抗泛素表现出一小部分的双重染色的神经突与抗体的神经丝或Alz-50，但没有双重染色的抗体阿尔茨海默氏症神经元缠结。这些结果与AD中的神经突不同，AD中的神经突在CA 2 -3中很少见到，并且与所有这些抗体免疫反应。海马CA 2 -3区的神经炎性变性似乎是DLBD的一个特定组织病理学特征。
Immunocytochemistry with antibodies to ubiquitin is currently the most sensitive method for detecting cortical Lewy bodies, which are a sine qua non for the diagnosis of diffuse Lewy body disease (DLBD), an increasingly recognized form of primary degenerative dementia. In the systematic application of ubiquitin immunocytochemistry to sections of hippocampus from control subjects and patients with a wide spectrum of neurodegenerative diseases, we noted the frequent occurrence of ubiquitin-immunoreactive neurites in the CA2–3 region in DLBD. The nature of these neurites was investigated with immunocytochemistry in DLBD, Alzheimer's disease (AD), normal elderly subjects, and Parkinson's disease (PD). Although the number of neurites varied from case to case, they were virtually always detected in DLBD but not in normal, AD, or PD brains. Double immunolabeling studies with anti-ubiquitin demonstrated a small fraction of double-stained neurites with antibodies to neurofilament or Alz-50, but no double staining with an antibody to Alzheimer neurofibrillary tangles. These results are different from those for neurites in AD, which are rarely seen in CA2–3 and which are immunoreactive with all these antibodies. Neuritic degeneration in the CA2–3 region of the hippocampus appears to be a specific histopathologic feature of DLBD.
影响因子：
56.9
作者：
GOLDMAN, JE;YEN, SH;PERESS, NS
通讯作者：
PERESS, NS
抗阿尔茨海默病神经原纤维缠结的单克隆抗体。
DOI：
--
发表时间：
1985
期刊：
The American journal of pathology
影响因子：
--
作者：
Dickson,DW;Kress,Y;Crowe,A;Yen,SH
通讯作者：
Yen,SH
正常人脑中的泛素免疫反应结构。
DOI：
--
发表时间：
1990
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Dickson,DW;Wertkin,A;Kress,Y;Ksiezak-Reding,H;Yen,SH
通讯作者：
Yen,SH