Human ocular mucins: The endowed guardians of sight.
Human ocular mucins: The endowed guardians of sight.
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DOI：
10.1016/j.addr.2021.114074
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发表时间：
2022-01
影响因子：
16.1
通讯作者：
Argüeso P
中科院分区：
文献类型：
--
作者：
Argüeso P
粘蛋白是一组古老的糖蛋白，其为浸泡湿表面上皮的流体提供粘弹性、润滑和水合性质。它们通过形成具有选择性渗透特性的屏障参与保护下层组织。粘蛋白的表达、加工和空间分布通常由器官特异性要求决定，所述器官特异性要求在眼睛中涉及在允许光通过的同时保护免受环境损害。人眼表上皮细胞已进化为产生极薄且含水的泪膜，其含有由杯状细胞在视轴外分泌的独特的可溶性粘蛋白产物。对眼部环境的适应性显著地通过跨膜粘蛋白对泪膜的显著贡献来证明，在泪膜中，它们可以占据其总厚度的四分之一。本文综述了人类眼粘蛋白的组织特异性，分离和检测方法，以及目前的方法来模拟人类眼表粘膜粘蛋白系统。这些知识构成了开发具有良好生物学和临床影响的应用的基本基础。
Mucins are an ancient group of glycoproteins that provide viscoelastic, lubricating and hydration properties to fluids bathing wet surfaced epithelia. They are involved in the protection of underlying tissues by forming a barrier with selective permeability properties. The expression, processing and spatial distribution of mucins are often determined by organ-specific requirements that in the eye involve protecting against environmental insult while allowing the passage of light. The human ocular surface epithelia have evolved to produce an extremely thin and watery tear film containing a distinct soluble mucin product secreted by goblet cells outside the visual axis. The adaptation to the ocular environment is notably evidenced by the significant contribution of transmembrane mucins to the tear film, where they can occupy up to one-quarter of its total thickness. This article reviews the tissue-specific properties of human ocular mucins, methods of isolation and detection, and current approaches to model mucin systems recapitulating the human ocular surface mucosa. This knowledge forms the fundamental basis to develop applications with a promising biological and clinical impact.
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影响因子：
4.1
作者：
Ang, LPK;Tan, DTH;Beuerman, RW
通讯作者：
Beuerman, RW
影响因子：
5.4
作者：
Ambort, Daniel;Johansson, Malin E. V.;Hansson, Gunnar C.
通讯作者：
Hansson, Gunnar C.
影响因子：
4.4
作者：
Argüeso, P;Tisdale, A;Gipson, IK
通讯作者：
Gipson, IK
影响因子：
3.4
作者：
CHAO, CCW;BUTALA, SM;HERP, A
通讯作者：
HERP, A
影响因子：
4.1
作者：
Asker, N;Axelsson, MAB;Hansson, GC
通讯作者：
Hansson, GC