Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons.
Dentate network activity is necessary for spatial working memory by supporting CA3 sharp-wave ripple generation and prospective firing of CA3 neurons.
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DOI：
10.1038/s41593-017-0061-5
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发表时间：
2018-03
影响因子：
25
通讯作者：
Leutgeb JK
中科院分区：
文献类型：
--
作者：
Sasaki T;Piatti VC;Hwaun E;Ahmadi S;Lisman JE;Leutgeb S;Leutgeb JK
复杂的空间工作记忆（WM）任务需要海马尖波涟漪（SWR）活动和齿状回（DG）神经元活动。因此，我们问是否DG输入CA3有助于空间WM促进SWR生成。大鼠在8臂迷宫中进行齿状核依赖性WM任务时，DG和CA3区的记录显示，在奖赏消耗过程中，齿状核神经元的活动和SWRs的发生率均增加。然后，我们发现减少奖励相关的CA3 SWR代没有直接输入齿状颗粒神经元。此外，CA3细胞与地方领域尚未访问的武器优先发射在回报位置的SWR期间，这些前瞻性的CA3发射模式更明显的正确的试验和齿状依赖。这些结果表明，协调CA 3神经元的活动模式DG是必要的神经元放电模式，支持目标导向的行为和记忆的产生。
Complex spatial working memory (WM) tasks have been shown to require both hippocampal sharp wave ripple (SWR) activity and dentate gyrus (DG) neuronal activity. We therefore asked whether DG inputs to CA3 contribute to spatial WM by promoting SWR generation. Recordings from DG and CA3 while rats performed a dentate-dependent WM task on an 8-arm radial maze revealed that the activity of dentate neurons and the incidence rate of SWRs both increased during reward consumption. We then found reduced reward-related CA3 SWR generation without direct input from dentate granule neurons. Furthermore, CA3 cells with place fields in not-yet visited arms preferentially fired during SWRs at reward locations, and these prospective CA3 firing patterns were more pronounced for correct trials and were dentate dependent. These results indicate that coordination of CA3 neuronal activity patterns by DG is necessary for the generation of neuronal firing patterns that support goal-directed behavior and memory.
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影响因子：
16.2
作者：
Carr MF;Karlsson MP;Frank LM
通讯作者：
Frank LM
影响因子：
16.2
作者：
Brandon MP;Koenig J;Leutgeb JK;Leutgeb S
通讯作者：
Leutgeb S
影响因子：
25
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
影响因子：
16.2
作者：
Danielson NB;Turi GF;Ladow M;Chavlis S;Petrantonakis PC;Poirazi P;Losonczy A
通讯作者：
Losonczy A
DOI：
10.1523/jneurosci.5110-11.2012
发表时间：
2012-05-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ahmed OJ;Mehta MR
通讯作者：
Mehta MR