The reorganization and reactivation of hippocampal maps predict spatial memory performance.
The reorganization and reactivation of hippocampal maps predict spatial memory performance.
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DOI：
10.1038/nn.2599
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发表时间：
2010-08
影响因子：
25
通讯作者：
Csicsvari, Jozsef
中科院分区：
文献类型：
--
作者：
Dupret, David;O'Neill, Joseph;Pleydell-Bouverie, Barty;Csicsvari, Jozsef
海马是空间记忆的关键脑回路，并且海马神经元组装体的空间选择性尖峰被认为提供了空间的记忆表示。在这里，我们表明，记住新学习的目标位置需要NMDA受体依赖的稳定和增强的目标相关的海马组件的再激活。在空间学习过程中，位置相关的放电模式在CA 1，但不是CA 3，区域的大鼠海马重组，以代表新的目标位置。当目标被视觉线索标记时，这种重组不会发生。这些新获得的CA 1表示行为相关的地方的稳定和成功检索是NMDAR依赖的和必要的后续记忆保持性能。目标相关的组装模式与尖锐的波/涟漪网络振荡，在学习和随后的休息期间，预测记忆性能。总之，这些结果表明，重组和重新激活的组装在海马放电模式代表了新的空间记忆痕迹的形成和表达。
The hippocampus is a key brain circuit for spatial memory, and the spatially-selective spiking of hippocampal neuronal assemblies is thought to provide a mnemonic representation of space. Here we show that remembering newly-learnt goal locations requires the NMDA receptor-dependent stabilization and enhanced reactivation of goal-related hippocampal assemblies. During spatial learning, place-related firing patterns in the CA1, but not CA3, region of the rat hippocampus were reorganized to represent new goal locations. Such reorganization did not occur when goals were marked by visual cues. The stabilization and successful retrieval of these newly-acquired CA1 representations for behaviorally-relevant places was NMDAR-dependent and necessary for subsequent memory retention performance. Goal-related assembly patterns associated with sharp wave/ripple network oscillations, during both learning and subsequent rest periods, predicted memory performance. Together, these results suggest that reorganization and reactivation of assembly firing patterns in the hippocampus represent the formation and expression of new spatial memory traces.
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影响因子：
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作者：
Hok, Vincent;Lenck-Santini, Pierre-Pascal;Poucet, Bruno
通讯作者：
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