Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions.
Type and orientation of yielded trabeculae during overloading of trabecular bone along orthogonal directions.
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DOI：
10.1016/j.jbiomech.2010.05.032
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发表时间：
2010-09-17
影响因子：
2.4
通讯作者：
Niebur, Glen L.
中科院分区：
文献类型：
--
作者：
Shi, Xiutao;Liu, X. Sherry;Wang, Xiang;Guo, X. Edward;Niebur, Glen L.
骨小梁结构在骨力学中起着重要作用。骨质疏松症导致骨小梁形态从板状转变为杆状，这可能导致骨折风险超过密度变化所预测的风险。在本研究中，使用个体骨小梁分割（ITS）分析了微观结构有限元分析结果，以确定在两个正交方向的压缩过载期间组织屈服的骨小梁的类型和方向。对于两种表观载荷条件，大部分屈服组织都出现在纵向板中。然而，与横向载荷的弯曲相比，屈服小梁的主要载荷模式是轴向压缩和轴向载荷的叠加弯曲。对于任一加载方向，大多数板状骨小梁在相同的加载模式下屈服，无论其方向如何。相反，平行于加载轴的棒在压缩时屈服，而倾斜或垂直于加载轴的棒在弯曲和拉伸组合时屈服。在轴向和横向过载过程中，接骨板中组织屈服的优势解释了轴向过载对离轴力学性能有害的原因。同时，在轴向和横向载荷下，平行于载荷方向的杆状小梁中的大部分组织屈服。因此，杆可能更容易受损，并可能通过损伤介导的重塑而被再吸收。
Trabecular architecture plays a major role in bone mechanics. Osteoporosis leads to a transition from a plate-like to a more rod-like trabecular morphology, which may contribute to fracture risk beyond that predicted by changes in density. In this study, microstructural finite element analysis results were analyzed using Individual Trabeculae Segmentation (ITS) to identify the type and orientation of trabeculae where tissue yielded during compressive overloads in two orthogonal directions. For both apparent loading conditions, most of the yielded tissue was found in longitudinally oriented plates. However, the primary loading mode of yielded trabeculae was axial compression with superposed bending for on-axis loading in contrast to bending for transverse loading. For either loading direction, most plate-like trabeculae yielded in the same loading mode, regardless of their orientation. In contrast, rods oriented parallel to the loading axis yielded in compression, while rods oblique or perpendicular to the loading axis yielded in combined bending and tension. The predominance of tissue yielding in plates during both on-axis and transverse overloading explains why on-axis overloading is detrimental to the off-axis mechanical properties. At the same time, a large fraction of the tissue in rod-like trabeculae parallel to the loading direction yielded in both on-axis and transverse loading. Hence, rods may be more likely to be damaged and potentially resorbed by damage mediated remodeling.
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影响因子：
4.1
作者：
Garrison, Jacqueline G.;Slaboch, Constance L.;Niebur, Glen L.
通讯作者：
Niebur, Glen L.
影响因子：
2.4
作者：
Bevill, Grant;Farhamand, Farhad;Keaveny, Tony M.
通讯作者：
Keaveny, Tony M.
DOI：
10.1115/1.2798314
发表时间：
1998-04-01
影响因子：
1.7
作者：
Guldberg, RE;Hollister, SJ;Charras, GT
通讯作者：
Charras, GT
DOI：
10.1115/1.2800865
发表时间：
1999-12-01
影响因子：
1.7
作者：
Niebur, GL;Yuen, JC;Keaveny, TM
通讯作者：
Keaveny, TM
DOI：
10.1359/jbmr.080517
发表时间：
2008-10
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Arlot ME;Burt-Pichat B;Roux JP;Vashishth D;Bouxsein ML;Delmas PD
通讯作者：
Delmas PD