Density and architecture have greater effects on the toughness of trabecular bone than damage.
Density and architecture have greater effects on the toughness of trabecular bone than damage.
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DOI：
10.1016/j.bone.2008.12.030
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发表时间：
2009-05
期刊：
影响因子：
4.1
通讯作者：
Niebur, Glen L.
中科院分区：
文献类型：
--
作者：
Garrison, Jacqueline G.;Slaboch, Constance L.;Niebur, Glen L.
骨损伤被认为是骨质量的一个重要方面。因此，了解损伤对骨小梁韧性的影响，应有助于了解能量受限情况下（如福尔斯）骨小梁的行为。本文研究了35个牛松质骨试件的损伤对韧性的影响。通过将轴上试样压缩至1.5%或2.5%应变，然后压缩至7.5%应变来诱导损伤。超载导致模量和弹性韧性的显着下降，高损伤组比低损伤组的降幅显着更大。损伤后，高损伤组的弹性韧性也低于对照组的未损伤弹性韧性。与此相反，有没有检测到的影响，损伤程度对韧性测量到7.5%的应变。韧性与骨密度呈线性关系（R2 = 0.50），与体积分数（BV/TV）呈幂律关系（R2 = 0.65）。微结构参数也预测的韧性在BV/TV或BMD的情况下。韧性下降，增加细长比（Tb. Sp/Tb. Th）和结构模型指数（SMI）（R2 = 0.68，多元回归），再次独立的损伤水平，这表明失败的影响小梁屈曲。两者合计，结果表明，由于密度和结构的韧性的正常变化占主导地位的变化，由于在本研究中引起的水平的损害。此外，测量韧性对最终应变敏感，因为在弹性和初始塑性区域中发现的差异在较高应变下是不可检测的。骨小梁中微裂纹的自限性或骨小梁结构本身可抑制微裂纹传播到宏观骨小梁骨折，从而限制损伤对韧性的影响，并使其与正常群体变异性相比难以检测。
Bone damage has been cited as an important aspect of bone quality. As such, understanding the effects of damage on the toughness of trabecular bone should provide insight into trabecular bone behavior during energy-limiting cases, such as falls. The effects of damage on the toughness of 35 bovine trabecular bone specimens was studied. Damage was induced by compressing the on-axis specimens to either 1.5% or 2.5% strain, followed by compression to 7.5% strain. The overloads resulted in significant decreases in both modulus and elastic toughness, with significantly greater decreases for the high-damage group than the low-damage group. Following damage, the elastic toughness of the high-damage group was also lower than the undamaged elastic toughness of the control group. In contrast, there was no detectable effect of damage level on toughness measured to 7.5% strain. Toughness increased linearly with BMD (R2 = 0.50) and by a power law relationship with volume fraction (BV/TV) (R2=0.65). Microarchitectural parameters also predicted the toughness in the absence of BV/TV or BMD. Toughness decreased with increasing slenderness ratio (Tb.Sp/Tb.Th) and structure model index (SMI) (R2=0.68, multiple regression), again independent of damage level, suggesting that failure is influenced by trabecular buckling. Taken together, the results show that normal variations in toughness due to density and architecture dominate the changes due to damage at the levels induced in this study. Moreover, measuring toughness is sensitive to the final strain, as differences found in the elastic and initial plastic regions were undetectable at higher strains. The self-limiting nature of microcracks in trabecular bone, or the trabecular architecture itself, may inhibit microcracks from propagating to macroscopic trabecular fractures, thereby limiting the effect of damage on toughness and making it difficult to detect in comparison to normal population variability.
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影响因子：
158.5
作者：
LIBERMAN, UA;WEISS, SR;KARPF, DB
通讯作者：
KARPF, DB
影响因子：
6.2
作者：
Komatsubara, S;Mori, K;Norimatsu, H
通讯作者：
Norimatsu, H
DOI：
10.1111/j.1532-5415.1994.tb06540.x
发表时间：
1994-07-01
影响因子：
6.3
作者：
CUMMING, RG;KLINEBERG, RJ
通讯作者：
KLINEBERG, RJ
影响因子：
2.4
作者：
KEAVENY, TM;WACHTEL, EF;HAYES, WC
通讯作者：
HAYES, WC
DOI：
10.1359/jbmr.080517
发表时间：
2008-10
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Arlot ME;Burt-Pichat B;Roux JP;Vashishth D;Bouxsein ML;Delmas PD
通讯作者：
Delmas PD