Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE).
Predictive value of early amplitude integrated electroencephalogram (aEEG) in sleep related problems in children with perinatal hypoxic-ischemia (HIE).
复制标题
早期振幅积分脑电图（aEEG）对围产期缺氧缺血（HIE）儿童睡眠相关问题的预测价值
DOI：
10.1186/s12887-021-02796-9
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发表时间：
2021-09-18
期刊：
影响因子：
2.4
通讯作者：
Ding X
中科院分区：
文献类型：
--
作者：
Tian Q;Pan Y;Zhang Z;Li M;Xu LX;Gong M;Miao P;Jiang X;Yang X;Feng CX;Pan J;Yu Y;Sun B;Ding X
背景虽然新生儿缺氧缺血性脑病（HIE）儿童的运动和认知障碍受到高度关注，但与睡眠相关的昼夜节律问题虽然普遍存在，但常常被忽视。随后，没有报道早期临床指标与发育过程中睡眠相关的昼夜节律功能障碍相关。方法在这项研究中，我们首先分析了一组患有不同程度 HIE 的新生儿的振幅积分脑电图 (aEEG) 模式。接下来，在随访过程中，我们收集了这些患者的睡眠和昼夜节律相关问题的信息，并进行了aEEG参数与不同睡眠/昼夜节律紊乱之间的相关性分析。结果共纳入101名新生儿。我们的结果表明，异常的aEEG背景模式与昼夜节律（r= 0.289，P= 0.01）和睡眠期间的呼吸问题（r= 0.237，P= 0.037）显着相关。相比之下，睡眠-觉醒周期（SWC）的建立与睡眠/昼夜节律问题没有相关性。详细分析表明，aEEG 评分的总和以及低基础电压（分别为 r= 0.272，P= 0.017 和 r= -0.228，P= 0.048）与睡眠昼夜节律问题相关。相反，背景模式（BP）评分与睡眠呼吸问题高度相关（r= 0.319，P= 0.004）。结论异常的新生儿aEEG模式与昼夜节律相关的睡眠问题相关。因此，我们的研究为 aEEG 对 HIE 儿童睡眠相关昼夜节律问题的预测价值提供了新的见解。
BackgroundWhile great attention has been paid to motor and cognitive impairments in children with neonatal Hypoxic-Ischemic Encephalopathy (HIE), sleep related circadian rhythm problems, although commonly present, are often neglected. Subsequently, no early clinical indicators have been reported to correlate with sleep-related circadian dysfunction during development.MethodsIn this study, we first analyzed patterns of the amplitude integrated electroencephalogram (aEEG) in a cohort of newborns with various degrees of HIE. Next, during follow-ups, we collected information of sleep and circadian related problems in these patients and performed correlation analysis between aEEG parameters and different sleep/circadian disorders.ResultsA total of 101 neonates were included. Our results demonstrated that abnormal aEEG background pattern is significantly correlated with circadian rhythmic (r= 0.289,P= 0.01) and breathing issues during sleep (r= 0.237,P= 0.037). In contrast, the establishment of sleep–wake cycle (SWC) showed no correlation with sleep/circadian problems. Detailed analysis showed that summation of aEEG score, along with low base voltage (r= 0.272,P= 0.017 andr= -0.228,P= 0.048, respectively), correlates with sleep circadian problems. In contrast, background pattern (BP) score highly correlates with sleep breathing problem (r= 0.319,P= 0.004).ConclusionAbnormal neonatal aEEG pattern is correlated with circadian related sleep problems. Our study thus provides novel insights into predictive values of aEEG in sleep-related circadian problems in children with HIE.
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