The role of cytology in the era of HPV-related head and neck carcinoma.

The role of cytology in the era of HPV-related head and neck carcinoma.
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细胞学在 HPV 相关头颈癌时代的作用。

DOI:
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发表时间:
2015
影响因子:
2.3
通讯作者:
S. Krishnamurthy
S. Krishnamurthy
中科院分区:
医学3区
文献类型:
--
作者:
S. Roy;S. Krishnamurthy

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在怀疑或证实为头颈部鳞状细胞癌的患者中,肿大的颈部淋巴结经常接受细针穿刺活检,以检测转移性疾病。常规评估此类患者中转移性癌的细胞学标本的人乳头瘤病毒(HPV),以确定患有HPV相关头颈部鳞状细胞癌的患者。不同类型的细胞学标本,包括涂片、细胞离心涂片、细胞块和冲洗液中的抽吸物质,都可用于不同类型的HPV检测,例如p16免疫组织化学、HPV原位杂交和HPV聚合酶链反应。目前还没有关于细胞学标本中高危HPV检测的共识。建立细胞学标本的标准化HPV检测是至关重要的,也是人们热切期待的。
Enlarged neck lymph nodes are very often subject to fine needle aspiration biopsy to detect metastatic disease in patients with suspected or proven squamous cell carcinoma in head and neck region. Cytology specimens of metastatic carcinoma in such patients are routinely evaluated for human papilloma virus (HPV) to identify patients with HPV-related head and neck squamous cell carcinoma. Different types of cytology specimens including smears, cytospins, cell blocks and aspirated material in the rinse can all be used for different types of HPV testing such as immunohistochemistry for p16, HPV-in situ hybridization, and HPV-Polymerase chain reaction. There is currently no consensus regarding the testing of high-risk HPV in cytology specimens. The establishment of standardized HPV testing of cytology specimens is of utmost importance and is eagerly awaited.
DOI: 10.1086/381504
发表时间: 2004-02-15
影响因子: 6.4
作者:
Kreimer, AR;Alberg, AJ;Gillison, ML
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