COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy.
COVID-19 one year into the pandemic: from genetics and genomics to therapy, vaccination, and policy.
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COVID-19 大流行一年：从遗传学和基因组学到治疗、疫苗接种和政策。
DOI：
10.1186/s40246-021-00326-3
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发表时间：
2021-05-10
期刊：
影响因子：
4.5
通讯作者：
Reichardt JKV
中科院分区：
文献类型：
--
作者：
Novelli G;Biancolella M;Mehrian-Shai R;Colona VL;Brito AF;Grubaugh ND;Vasiliou V;Luzzatto L;Reichardt JKV
新冠肺炎已经吞噬了世界，它将在未来一段时间里陪伴着我们所有人。在这里，我们回顾了世界卫生组织(WHO)宣布的大流行一周年的里程碑时期的当前状态。我们回顾了正在进行的大流行的几个方面，首先集中在两个主要主题：病毒变异和人类对疾病严重程度的遗传易感性。然后，我们考虑最近和令人兴奋的新发展，在治疗学，如单克隆抗体，和在预防战略，如疫苗。我们还简要讨论了在全球紧急情况的威胁下，基础科学和生物技术的进步如何加速到前所未有的程度，从实验室过渡到临床应用。虽然我们每天都获得越来越多的工具来应对正在进行的大流行，但我们意识到，道路将是艰难的，这将要求我们所有人都具有社区意识。在这方面，我们对过去在及时全面调查方面的拖延表示遗憾，我们呼吁为了各大洲人类的利益绕过地方政治。网上版载有补充材料，可在10.1186/s40246-021-00326-3查阅。
COVID-19 has engulfed the world and it will accompany us all for some time to come. Here, we review the current state at the milestone of 1 year into the pandemic, as declared by the WHO (World Health Organization). We review several aspects of the on-going pandemic, focusing first on two major topics: viral variants and the human genetic susceptibility to disease severity. We then consider recent and exciting new developments in therapeutics, such as monoclonal antibodies, and in prevention strategies, such as vaccines. We also briefly discuss how advances in basic science and in biotechnology, under the threat of a worldwide emergency, have accelerated to an unprecedented degree of the transition from the laboratory to clinical applications. While every day we acquire more and more tools to deal with the on-going pandemic, we are aware that the path will be arduous and it will require all of us being community-minded. In this respect, we lament past delays in timely full investigations, and we call for bypassing local politics in the interest of humankind on all continents. The online version contains supplementary material available at 10.1186/s40246-021-00326-3.
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DOI：
10.1056/nejmoa2029849
发表时间：
2021-01-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Chen P;Nirula A;Heller B;Gottlieb RL;Boscia J;Morris J;Huhn G;Cardona J;Mocherla B;Stosor V;Shawa I;Adams AC;Van Naarden J;Custer KL;Shen L;Durante M;Oakley G;Schade AE;Sabo J;Patel DR;Klekotka P;Skovronsky DM;BLAZE-1 Investigators
通讯作者：
BLAZE-1 Investigators
影响因子：
64.8
作者：
BRENNER, S;MESELSON, M;JACOB, F
通讯作者：
JACOB, F
DOI：
10.1073/pnas.1510199112
发表时间：
2015-08-18
影响因子：
11.1
作者：
Corti, Davide;Zhao, Jincun;Lanzavecchia, Antonio
通讯作者：
Lanzavecchia, Antonio
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
64.5
作者：
Andreano E;Nicastri E;Paciello I;Pileri P;Manganaro N;Piccini G;Manenti A;Pantano E;Kabanova A;Troisi M;Vacca F;Cardamone D;De Santi C;Torres JL;Ozorowski G;Benincasa L;Jang H;Di Genova C;Depau L;Brunetti J;Agrati C;Capobianchi MR;Castilletti C;Emiliozzi A;Fabbiani M;Montagnani F;Bracci L;Sautto G;Ross TM;Montomoli E;Temperton N;Ward AB;Sala C;Ippolito G;Rappuoli R
通讯作者：
Rappuoli R