Immune-Based Anti-Staphylococcal Therapeutic Approaches.
Immune-Based Anti-Staphylococcal Therapeutic Approaches.
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DOI：
10.3390/microorganisms9020328
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发表时间：
2021-02-06
期刊：
影响因子：
4.5
通讯作者：
Liu GY
中科院分区：
文献类型：
--
作者：
Park B;Liu GY
广泛存在的耐甲氧西林金黄色葡萄球菌（S。金黄色葡萄球菌）感染是加速抗生素耐药性发展的原因。随着抗生素管道开始枯竭，为未来治疗S寻求替代策略。金黄色葡萄球菌感染在这里，我们回顾了基于免疫的抗葡萄球菌策略，与传统的抗生素不同，靶向病原体阐述的非必需基因产物。这些策略刺激对抗葡萄球菌防御至关重要的窄或宽宿主免疫机制。替代方法旨在破坏增强病原体存活或诱导免疫病理学的细菌毒力机制。虽然基于免疫的疗法不太可能在短期内取代抗生素治疗患者，但它们有可能显著改善抗生素治疗侵袭性葡萄球菌疾病的性能。
Widespread methicillin-resistant Staphylococcus aureus (S. aureus) infections within community and healthcare settings are responsible for accelerated development of antibiotic resistance. As the antibiotic pipeline began drying up, alternative strategies were sought for future treatment of S. aureus infections. Here, we review immune-based anti-staphylococcal strategies that, unlike conventional antibiotics, target non-essential gene products elaborated by the pathogen. These strategies stimulate narrow or broad host immune mechanisms that are critical for anti-staphylococcal defenses. Alternative approaches aim to disrupt bacterial virulence mechanisms that enhance pathogen survival or induce immunopathology. Although immune-based therapeutics are unlikely to replace antibiotics in patient treatment in the near term, they have the potential to significantly improve upon the performance of antibiotics for treatment of invasive staphylococcal diseases.
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影响因子：
4.5
作者：
Armentrout EI;Liu GY;Martins GA
通讯作者：
Martins GA
影响因子：
4.8
作者：
Anderson AS;Miller AA;Donald RG;Scully IL;Nanra JS;Cooper D;Jansen KU
通讯作者：
Jansen KU
影响因子：
11.8
作者：
Fritz, Stephanie A.;Tiemann, Kristin M.;Hunstad, David A.
通讯作者：
Hunstad, David A.
影响因子：
11.8
作者：
Freifeld, Alison G.;Bow, Eric J.;Wingard, John R.
通讯作者：
Wingard, John R.
DOI：
10.1093/infdis/jiz692
发表时间：
2020-11-09
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Ciarlo E;Heinonen T;Théroude C;Asgari F;Le Roy D;Netea MG;Roger T
通讯作者：
Roger T