Development of a multicomponent Staphylococcus aureus vaccine designed to counter multiple bacterial virulence factors.
Development of a multicomponent Staphylococcus aureus vaccine designed to counter multiple bacterial virulence factors.
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DOI：
10.4161/hv.21872
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发表时间：
2012-11-01
影响因子：
4.8
通讯作者：
Jansen KU
中科院分区：
文献类型：
--
作者：
Anderson AS;Miller AA;Donald RG;Scully IL;Nanra JS;Cooper D;Jansen KU
金黄色葡萄球菌是医疗保健相关感染的主要原因，并对住院患者的疾病造成重大负担。尽管感染控制指南越来越严格，但金黄色葡萄球菌感染的流行率和相应的负面影响仍然很大。控制金黄色葡萄球菌感染的困难以及相关的治疗费用因对现有抗生素的耐药率增加而加剧。尽管在过去20年里一直在努力，但目前还没有获得许可的金黄色葡萄球菌疫苗。然而，从过去候选疫苗的临床失败中吸取教训，以及对金黄色葡萄球菌定植和感染的免疫病理学的更好理解，有助于基于多种重要的细菌致病机制设计新的候选疫苗。这篇综述概述了在医疗保健环境中设计预防金黄色葡萄球菌病的疫苗时需要考虑的重要因素。
Staphylococcus aureus is a major cause of healthcare-associated infections and is responsible for a substantial burden of disease in hospitalized patients. Despite increasingly rigorous infection control guidelines, the prevalence and corresponding negative impact of S. aureus infections remain considerable. Difficulties in controlling S. aureus infections as well as the associated treatment costs are exacerbated by increasing rates of resistance to available antibiotics. Despite ongoing efforts over the past 20 years, no licensed S. aureus vaccine is currently available. However, learnings from past clinical failures of vaccine candidates and a better understanding of the immunopathology of S. aureus colonization and infection have aided in the design of new vaccine candidates based on multiple important bacterial pathogenesis mechanisms. This review outlines important considerations in designing a vaccine for the prevention of S. aureus disease in healthcare settings.
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影响因子：
3.1
作者：
Fattom, AI;Sarwar, J;Naso, R
通讯作者：
Naso, R
DOI：
10.1093/infdis/jis272
发表时间：
2012-06
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Anderson AS;Scully IL;Timofeyeva Y;Murphy E;McNeil LK;Mininni T;Nuñez L;Carriere M;Singer C;Dilts DA;Jansen KU
通讯作者：
Jansen KU
影响因子：
36.8
作者：
FIGUEROA, JE;DENSEN, P
通讯作者：
DENSEN, P
影响因子：
5.1
作者：
Dejonge, Mitchell;Burchfield, David;Hetherington, Seth
通讯作者：
Hetherington, Seth
影响因子：
4.8
作者：
Cheng, Alice G.;Kim, Hwan Keun;Missiakas, Dominique M.
通讯作者：
Missiakas, Dominique M.