Predictors of iron levels in 14,737 Danish blood donors: results from the Danish Blood Donor Study.
Predictors of iron levels in 14,737 Danish blood donors: results from the Danish Blood Donor Study.
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DOI：
10.1111/trf.12518
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发表时间：
2014-03
期刊：
影响因子：
2.9
通讯作者：
Ullum H
中科院分区：
文献类型：
--
作者：
Rigas AS;Sørensen CJ;Pedersen OB;Petersen MS;Thørner LW;Kotzé S;Sørensen E;Magnussen K;Rostgaard K;Erikstrup C;Ullum H
膳食研究表明，一般人群中铁增强剂和抑制剂的摄入量与铁储存量之间存在关系。然而，饮食因素对献血者铁储存的影响，其铁状态受献血的影响，还不完全清楚。在丹麦献血者研究中，我们评估了献血频率、生理因素、生活方式和补充因素以及饮食因素对铁蛋白水平的影响。我们使用按性别和更年期状态分层的多元线性和逻辑回归分析。在高频献血者（过去3年中超过9次献血）中，我们发现分别有9%、39%和22%的男性、绝经前女性和绝经后女性缺铁（铁蛋白低于15 ng/mL）。铁缺乏的最强预测因素是性别、绝经状态、3年内献血次数和距上次献血的时间。其他重要因素包括体重、年龄、月经强度、铁片、维生素片以及肉类和葡萄酒的消费。这项研究证实缺铁是一个重要的问题，特别是在经常献血的孕妇中。铁缺乏的风险主要由性别、绝经状态和献血频率解释。其他因素，包括饮食和补充铁摄入量，对铁耗竭风险的影响要弱得多。
Dietary studies show a relationship between the intake of iron enhancers and inhibitors and iron stores in the general population. However, the impact of dietary factors on the iron stores of blood donors, whose iron status is affected by blood donations, is incompletely understood. In the Danish Blood Donor Study, we assessed the effect of blood donation frequency, physiologic factors, lifestyle and supplemental factors, and dietary factors on ferritin levels. We used multiple linear and logistic regression analyses stratified by sex and menopausal status. Among high-frequency donors (more than nine donations in the past 3 years), we found iron deficiency (ferritin below 15 ng/mL) in 9, 39, and 22% of men, premenopausal women, and postmenopausal women, respectively. The strongest predictors of iron deficiency were sex, menopausal status, the number of blood donations in a 3-year period, and the time since last donation. Other significant factors included weight, age, intensity of menstruation, iron tablets, vitamin pills, and consumption of meat and wine. The study confirms iron deficiency as an important problem, especially among menstruating women donating frequently. The risk of iron depletion was largely explained by sex, menopausal status, and donation frequency. Other factors, including dietary and supplemental iron intake, had a much weaker effect on the risk of iron depletion.
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影响因子：
4.2
作者：
Oppenheimer, SJ
通讯作者：
Oppenheimer, SJ
影响因子：
4.3
作者：
MILMAN, N;ROSDAHL, N;GRAUDAL, N
通讯作者：
GRAUDAL, N
影响因子：
7.1
作者：
Hurrell, Richard;Egli, Ines
通讯作者：
Egli, Ines
影响因子：
7.1
作者：
Casgrain, Amelie;Collings, Rachel;Fairweather-Tait, Susan J.
通讯作者：
Fairweather-Tait, Susan J.
影响因子：
7
作者：
Fairweather-Tait, SJ
通讯作者：
Fairweather-Tait, SJ