Long non-coding RNA00544 serves as a potential novel predictive and prognostic marker for HR+ HER2- subtype breast cancer.
Long non-coding RNA00544 serves as a potential novel predictive and prognostic marker for HR+ HER2- subtype breast cancer.
复制标题
长非编码RNA00544可作为HR HER2亚型乳腺癌的潜在新型预测和预后标志物
DOI：
10.1038/s41598-017-11066-7
复制
发表时间：
2017-09-28
影响因子：
4.6
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Liu L;Chi Y;Chen J;Xue J;Deng L;Huang N;Shao J;Wu J
管腔型乳腺癌（Luminal breast cancer，BC）占乳腺癌的绝大多数。由于其异质性和治疗耐药性的发展，管腔BC患者可能差异很大。众所周知，长链非编码RNA（lncRNA）参与了乳腺癌的进展。在这里，我们的目标是确定lncRNA参与特定类型的管腔BC进展。通过基因芯片分析，我们发现了一个新的lncRNA 00544，它在转移性腋窝淋巴结中的表达高于相应的管腔BC组织（倍数变化= 2.26，P = 0.043）。该结果在管腔BC细胞系（p = 0.0113）和49个配对乳腺癌样品中与相应对照（p = 0.011）相比得到证实。此外，373名乳腺癌患者的Kaplan-Meier生存曲线表明，在具有高lncRNA 00544表达的乳腺癌患者中，无病生存率显著较差（p < 0.001）。单变量和多变量考克斯回归分析显示，lncRNA 00544是管腔型BC患者中显著的独立预后生物标志物。进一步分析发现，乳腺癌患者lncRNA 00544高表达的预后实际上与HR + HER 2 −亚型有关。总之，我们的研究表明，lncRNA 00544可能代表一种新的预测和预后指标管腔BC患者。
Luminal breast cancers (BC) account for majority of breast cancer. Due to its heterogeneity and the development of treatment resistance, luminal BC patients can vary substantially. Long noncoding RNAs (lncRNAs), as we known, is involved in breast cancer progression. Here, we aim to identify the lncRNAs which are involved in the particular type luminal BC progression. By Gene Chips analysis, we found a novel lncRNA00544, which was highly expressed in the metastatic axillary nodes compared with corresponding luminal BC tissues (fold change = 2.26, P = 0.043). This result was confirmed in luminal BC cell lines (p = 0.0113) and 49 paired breast cancer samples compared with in corresponding controls (p = 0.011). Furthermore, Kaplan–Meier survival curves of 373 breast cancer patients indicated that disease-free survival was significantly poor in breast cancer patients with high lncRNA00544 expression (p < 0.001). Univariate and multivariate Cox regression analyses showed that lncRNA00544 was a significant independent prognostic biomarker in luminal BC patients. Further analysis showed that the prognosis of high lncRNA00544 expression in breast cancer patients was actually related to HR + HER2− subtype. Together, our studies indicate that lncRNA00544 may represent a novel predictive and prognostic indicator in luminal BC patients.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
5.4
作者：
Kornienko AE;Guenzl PM;Barlow DP;Pauler FM
通讯作者：
Pauler FM
影响因子：
5.2
作者：
He, Dong-Xu;Zhang, Guang-Yuan;Ma, Xin
通讯作者：
Ma, Xin
影响因子：
3.7
作者：
van Agthoven T;Dorssers LC;Lehmann U;Kreipe H;Looijenga LH;Christgen M
通讯作者：
Christgen M
影响因子：
5
作者：
Azim HA;Kassem L;Treilleux I;Wang Q;El Enein MA;Anis SE;Bachelot T
通讯作者：
Bachelot T