Time efficient whole-brain coverage with MR Fingerprinting using slice-interleaved echo-planar-imaging.
Time efficient whole-brain coverage with MR Fingerprinting using slice-interleaved echo-planar-imaging.
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DOI：
10.1038/s41598-018-24920-z
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发表时间：
2018-04-27
影响因子：
4.6
通讯作者：
Schad LR
中科院分区：
文献类型：
--
作者：
Rieger B;Akçakaya M;Pariente JC;Llufriu S;Martinez-Heras E;Weingärtner S;Schad LR
磁共振指纹分析(MRF)是一种快速同时定量多个组织参数的有效方法。本研究的目的是通过使用切片交错捕获方案来提高基于回波平面成像的MRF的覆盖率。为此，MRF-EPI被修改为以随机交织的方式获取多个切片，从而增加了每个切片中损坏的梯度回波读出采集的有效重复时间。信号轨迹与预计算词典的逐片匹配允许生成具有集成的B1+校正的T1和T2*图。随后对线圈灵敏度曲线的补偿和对脑脊液的归一化还允许定量的质子密度(PD)映射。进行了数值模拟以优化交错切片的数量。在体模扫描中验证了量化的准确性，并在体内证明了可行性。数值模拟表明，获取四个切片是量化精度和扫描时间之间的折衷。体模结果与参考测量结果吻合良好(差T1：−2.4 ± 1.1%，T2*：−0.5 ± 2.5%，PD：−0.5 ± 7.2%)。在3：36 分钟内获得了32层的T1、T2*和PD的活体全脑覆盖，从而获得了高视觉质量的参数图，扫描时间减少了4倍，性能与单层磁共振成像相当。
Magnetic resonance fingerprinting (MRF) is a promising method for fast simultaneous quantification of multiple tissue parameters. The objective of this study is to improve the coverage of MRF based on echo-planar imaging (MRF-EPI) by using a slice-interleaved acquisition scheme. For this, the MRF-EPI is modified to acquire several slices in a randomized interleaved manner, increasing the effective repetition time of the spoiled gradient echo readout acquisition in each slice. Per-slice matching of the signal-trace to a precomputed dictionary allows the generation of T1 and T2* maps with integrated B1+ correction. Subsequent compensation for the coil sensitivity profile and normalization to the cerebrospinal fluid additionally allows for quantitative proton density (PD) mapping. Numerical simulations are performed to optimize the number of interleaved slices. Quantification accuracy is validated in phantom scans and feasibility is demonstrated in-vivo. Numerical simulations suggest the acquisition of four slices as a trade-off between quantification precision and scan-time. Phantom results indicate good agreement with reference measurements (Difference T1: −2.4 ± 1.1%, T2*: −0.5 ± 2.5%, PD: −0.5 ± 7.2%). In-vivo whole-brain coverage of T1, T2* and PD with 32 slices was acquired within 3:36 minutes, resulting in parameter maps of high visual quality and comparable performance with single-slice MRF-EPI at 4-fold scan-time reduction.
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