Glycosphingolipids of Human Peripheral Nervous System Myelins Isolated from Cauda Equina
Glycosphingolipids of Human Peripheral Nervous System Myelins Isolated from Cauda Equina
复制标题
从马尾分离的人周围神经系统髓磷脂的糖鞘脂
DOI：
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发表时间：
1993
影响因子：
4.7
通讯作者：
K. Nagashima
中科院分区：
文献类型：
--
作者：
K. Ogawa‐Goto;Y. Ohta;K. Kubota;N. Funamoto;T. Abe;T. Taki;K. Nagashima
翻译后摘要：中性和硫酸化葡萄糖醛酸鞘糖脂纯化人类运动和感觉神经和髓鞘的组合物进行了研究。通过TLC和TLC免疫染色分析从GazlCer（级分A）分离的较高中性鞘糖脂（级分B）。两种神经髓鞘含有paragloboside（nLc 4Cer）和nLc 6Cer占主导地位的主要较高的鞘糖脂和非常少的globoside（Gb 4Cer），而两种神经含有Gb 4Cer和nLc 4Cer。除了这些主要的鞘糖脂，中性糖脂含有asialoGMI（Gg 4Cer）表位和其他次要成分，如神经酰胺三己糖苷和神经酰胺二己糖苷中检测到的神经和他们的髓鞘。此外，在神经和髓鞘中均检测到硫酸化葡萄糖醛酸nLc 4Cer和nLc 6Cer，它们是单克隆抗体HNK-1反应性糖脂。
Abstract: Compositions of neutral and sulfated glucuronyl glycosphingolipids purified from human motor and sensory nerves and myelins were studied. Higher neutral glycosphingolipids (fraction B), which were separated from GazlCer (fraction A), were analyzed by TLC and TLC‐immunostaining. Both nerve myelins contained paragloboside (nLc4Cer) and nLc6Cer dominantly as major higher glycosphingolipids and very little globoside (Gb4Cer), whereas both nerves contained Gb4Cer and nLc4Cer. Besides these major glycosphingolipids, a neutral glycolipid containing asialoGMI (Gg4Cer) epitope and other minor components such as ceramide trihexoside and ceramide dihexoside were detected in both nerves and their myelins. Furthermore, sulfated glucuronyl nLc4Cer and n Lc6Cer, which were monoclonal antibody HNK‐1 reactive glycolipids, were detected in both nerves and myelins.
针对人类癌细胞系的小鼠单克隆抗体，对血型和相关抗原具有特异性。
DOI：
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发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Hansson,GC;Karlsson,KA;Larson,G;McKibbin,JM;Blaszczyk,M;Herlyn,M;Steplewski,Z;Koprowski,H
通讯作者：
Koprowski,H
神经系统诱导、组织发生和围产期发育过程中细胞粘附的调节。
影响因子：
13.9
作者：
Edelman,GM
通讯作者：
Edelman,GM
吉兰-巴利综合征中的抗外周神经髓磷脂抗体与外周髓磷脂的中性糖脂结合，并与福斯曼抗原发生交叉反应。
DOI：
10.1172/jci114152
发表时间：
1989
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Koski,CL;Chou,DK;Jungalwala,FB
通讯作者：
Jungalwala,FB