High protein intake is associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study.
High protein intake is associated with low prevalence of frailty among old Japanese women: a multicenter cross-sectional study.
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DOI：
10.1186/1475-2891-12-164
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发表时间：
2013-12-19
影响因子：
5.4
通讯作者：
Three-generation Study of Women on Diets and Health Study Group
中科院分区：
文献类型：
--
作者：
Kobayashi S;Asakura K;Suga H;Sasaki S;Three-generation Study of Women on Diets and Health Study Group
蛋白质摄入量与虚弱程度呈负相关。然而，没有研究检查蛋白质来源（动物或植物）或组成蛋白质的氨基酸的差异对脆弱性的影响。因此，我们研究了蛋白质和氨基酸摄入量与日本老年妇女虚弱的关系。共有2108名65岁及以上饮食学生的祖母或熟人参加了这项横断面多中心研究，该研究在日本35个都道府县的85所饮食学校进行。总的，动物和植物蛋白质和八种选定的氨基酸的摄入量进行了估计，从一个有效的自我管理的饮食史问卷和氨基酸组成数据库。虚弱被定义为存在以下四个组成部分中的三个或更多个：缓慢和虚弱（两个点），疲惫，体力活动少和无意的体重减轻。虚弱受试者数量为481例（23%）。总蛋白质摄入量的第一、第二、第三、第四和第五个五分位数中，虚弱的校正OR（95% CI）为1.00（参考）、1.02（0.72，1.45）、0.64（0.45，0.93）、0.62（0.43，0.90）和0.66（0.46，0.96）（趋势P = 0.001）。总蛋白质摄入量分为第三、第四和第五个五分位数的受试者（>69.8 g/d）的OR显著低于第一个五分位数的受试者（均P <0.03）。动物和植物蛋白质以及所有选定氨基酸的摄入量也与虚弱呈负相关（趋势P <0.04），与动物蛋白和植物蛋白的最低五分位数0.73和0.66相比，多变量调整OR最高，氨基酸为0.67-0.74，尽管这些饮食变量的OR值不如总蛋白的显著。总蛋白质摄入量与日本老年妇女的虚弱程度呈显著负相关。无论蛋白质的来源和组成蛋白质的氨基酸如何，都可以观察到总蛋白质与脆弱性的关联。
Protein intake has been inversely associated with frailty. However, no study has examined the effect of the difference of protein sources (animal or plant) or the amino acid composing the protein on frailty. Therefore, we examined the association of protein and amino acid intakes with frailty among elderly Japanese women. A total of 2108 grandmothers or acquaintances of dietetic students aged 65 years and older participated in this cross-sectional multicenter study, which was conducted in 85 dietetic schools in 35 prefectures of Japan. Intakes of total, animal, and plant protein and eight selected amino acids were estimated from a validated brief-type self-administered diet history questionnaire and amino acid composition database. Frailty was defined as the presence of three or more of the following four components: slowness and weakness (two points), exhaustion, low physical activity, and unintentional weight loss. The number of subjects with frailty was 481 (23%). Adjusted ORs (95% CI) for frailty in the first, second, third, fourth, and fifth quintiles of total protein intake were 1.00 (reference), 1.02 (0.72, 1.45), 0.64 (0.45, 0.93), 0.62 (0.43, 0.90), and 0.66 (0.46, 0.96), respectively (P for trend = 0.001). Subjects categorized to the third, fourth, and fifth quintiles of total protein intake (>69.8 g/d) showed significantly lower ORs than those to the first quintile (all P <0.03). The intakes of animal and plant protein and all selected amino acids were also inversely associated with frailty (P for trend <0.04), with the multivariate adjusted OR in the highest compared to the lowest quintile of 0.73 for animal protein and 0.66 for plant protein, and 0.67-0.74 for amino acids, albeit that the ORs for these dietary variables were less marked than those for total protein. Total protein intake was significantly inversely associated with frailty in elderly Japanese women. The association of total protein with frailty may be observed regardless of the source of protein and the amino acid composing the protein.
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影响因子：
7.2
作者：
Fukuhara, S;Bito, S;Kurokawa, K
通讯作者：
Kurokawa, K
影响因子：
5
作者：
WILLETT, W;STAMPFER, MJ
通讯作者：
STAMPFER, MJ
影响因子：
3.9
作者：
Doba, Nobutaka;Tokuda, Yasuharu;Hinohara, Shigeaki
通讯作者：
Hinohara, Shigeaki
DOI：
10.1093/gerona/61.6.589
发表时间：
2006-06-01
影响因子：
5.1
作者：
Bartali, Benedetta;Frongillo, Edward A.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
1.3
作者：
Suga, Hitomi;Murakami, Kentaro;Sasaki, Satoshi
通讯作者：
Sasaki, Satoshi