Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut.
Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut.
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DOI：
10.1016/j.mib.2010.12.012
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发表时间：
2011-02
影响因子：
5.4
通讯作者：
Finlay BB
中科院分区：
文献类型：
--
作者：
Keeney KM;Finlay BB
肠道内有一个大型的微生物群落，统称为微生物群。该群落通过将难消化的食物产品分解为宿主和微生物群都使用的代谢物来产生复杂的营养环境。入侵的肠道病原体和微生物群都竞争这些代谢物，这些代谢物可以塑造植物群的组成以及对感染的易感性。感染建立后，病原体介导的炎症改变了微生物群的组成，这进一步改变了胃肠道中代谢物的组成。更好地了解微生物群，它们产生的代谢产物和对肠道疾病的易感性之间的相互作用将有助于发现对抗感染性疾病的新疗法。
Residing within the intestine is a large community of commensal organisms collectively termed the microbiota. This community generates a complex nutrient environment by breaking down indigestible food products into metabolites that are used by both the host and the microbiota. Both the invading intestinal pathogen and the microbiota compete for these metabolites, which can shape both the composition of the flora, as well as susceptibility to infection. After infection is established, pathogen mediated inflammation alters the composition of the microbiota, which further shifts the makeup of metabolites in the gastrointestinal tract. A greater understanding of the interplay between the microbiota, the metabolites they generate, and susceptibility to enteric disease will enable the discovery of novel therapies against infectious disease.
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影响因子：
3.1
作者：
FRETER, R;BRICKNER, H;CAREY, KE
通讯作者：
CAREY, KE
影响因子：
3.2
作者：
Huang, Yanyan;Suyemoto, Mitsu;Altier, Craig
通讯作者：
Altier, Craig
影响因子：
3.6
作者：
Hendrixson, DR;DiRita, VJ
通讯作者：
DiRita, VJ
影响因子：
3.1
作者：
Jones, Shari A.;Jorgensen, Mathias;Conway, Tyrrell
通讯作者：
Conway, Tyrrell
影响因子：
6.7
作者：
Endt K;Stecher B;Chaffron S;Slack E;Tchitchek N;Benecke A;Van Maele L;Sirard JC;Mueller AJ;Heikenwalder M;Macpherson AJ;Strugnell R;von Mering C;Hardt WD
通讯作者：
Hardt WD