Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease.
Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease.
复制标题
萝卜硫素治疗阿尔茨海默病的临床前神经保护证据和可能的机制。
DOI：
10.3390/ijms22062929
复制
发表时间：
2021-03-13
影响因子：
5.6
通讯作者：
Kim J
中科院分区：
文献类型：
--
作者：
Kim J
萝卜硫素是从十字花科蔬菜中获得的一种有效的膳食生物活性物质，因其在疾病预防和治疗中的作用而被广泛研究。萝卜硫素能有效地诱导转录因子核因子红系相关因子2(NRF2)介导的解毒、抗氧化和免疫系统调节酶的表达，并可能作为一种抗癌药物。几项临床试验正在进行中，以研究不同类型的十字花科蔬菜和萝卜硫素对前列腺癌、乳腺癌、肺癌、特应性哮喘、皮肤老化、皮炎、肥胖等的影响。最近，萝卜硫素对大脑健康的保护作用也得到了大量研究，研究进一步扩展到几种神经系统疾病，包括阿尔茨海默病(AD)、帕金森氏病、亨廷顿病、肌萎缩侧索硬化症、多发性硬化症、自闭症谱系障碍和精神分裂症。综述了萝卜硫素治疗记忆障碍的动物和细胞研究，以及与AD相关的淀粉样蛋白-β、tau、炎症、氧化应激和神经变性的临床前生物标志物，并讨论了萝卜硫素有助于预防AD的可能的神经保护机制。临床前证据的增加一致表明萝卜硫素对AD的病理生理具有多方面的神经保护作用。在细胞和动物中发现的萝卜硫素类抗AD证据表明，有必要在AD症状前期人群中进行萝卜硫素相关生物标记物的研究。
Sulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has been extensively studied for its effects in disease prevention and therapy. Sulforaphane potently induces transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated expression of detoxification, anti-oxidation, and immune system-modulating enzymes, and possibly acts as an anti-carcinogenic agent. Several clinical trials are in progress to study the effect of diverse types of cruciferous vegetables and sulforaphane on prostate cancer, breast cancer, lung cancer, atopic asthmatics, skin aging, dermatitis, obesity, etc. Recently, the protective effects of sulforaphane on brain health were also considerably studied, where the studies have further extended to several neurological diseases, including Alzheimer’s disease (AD), Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, autism spectrum disorder, and schizophrenia. Animal and cell studies that employ sulforaphane against memory impairment and AD-related pre-clinical biomarkers on amyloid-β, tau, inflammation, oxidative stress, and neurodegeneration are summarized, and plausible neuroprotective mechanisms of sulforaphane to help prevent AD are discussed. The increase in pre-clinical evidences consistently suggests that sulforaphane has a multi-faceted neuroprotective effect on AD pathophysiology. The anti-AD-like evidence of sulforaphane seen in cells and animals indicates the need to pursue sulforaphane research for relevant biomarkers in AD pre-symptomatic populations.
登录
查看更多内容
影响因子：
12.6
作者：
Du X;Wang X;Geng M
通讯作者：
Geng M
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
3.6
作者：
Charron, Craig S.;Vinyard, Bryan T.;Novotny, Janet A.
通讯作者：
Novotny, Janet A.
影响因子：
16.6
作者：
Jo, Chulman;Gundemir, Soner;Pritchard, Susanne;Jin, Youngnam N.;Rahman, Irfan;Johnson, Gail V. W.
通讯作者：
Johnson, Gail V. W.
影响因子：
4.2
作者：
An, Ye Won;Jhang, Kyoung A.;Chong, Young Hae
通讯作者：
Chong, Young Hae