Antiplatelet effects of qishen yiqi dropping pill in platelets aggregation in hyperlipidemic rabbits.
Antiplatelet effects of qishen yiqi dropping pill in platelets aggregation in hyperlipidemic rabbits.
复制标题
芪参益气滴丸对高脂兔血小板聚集的抗血小板作用
DOI：
10.1155/2012/205451
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Gao X
中科院分区：
文献类型：
--
作者：
Wang Y;Wang J;Guo L;Gao X
目的：观察芪参益气滴丸对血小板聚集的影响，并探讨其作用机制。采用高脂/高胆固醇饲料造成家兔高脂血症模型6周，观察QSYQ 2.0，1.0，0.5g/kg的治疗作用。给药14 d后，模型组兔由二磷酸腺苷（ADP）、花生四烯酸（AA）和胶原（科尔）诱导的血小板聚集率明显降低。结果表明，QSYQ能显著降低β-血小板球蛋白（β-TG）水平，但对P-选择素和血小板第4因子（PF 4）无明显影响; QSYQ能显著降低血栓素B2（TXB 2）/6-酮-前列腺素F1α（6-Keto-PGF 1 α）比值，升高环磷酸腺苷（cAMP）水平。综上所述，QSYQ可改善高脂血症家兔血小板聚集，抑制β-TG的过度释放，其作用机制可能与提高cAMP水平有关。提示QSYQ的抗血小板聚集作用可能与其提高cAMP水平，改善cAMP代谢有关。
We investigated the effects of Qishen Yiqi Dropping Pill (QSYQ) on platelets aggregation and its possible mechanisms. Hyperlipidemic model in rabbits was produced by a high fat/cholesterol diet for 6 weeks, the therapeutic effect of QSYQ with 2.0 g/kg, 1.0 g/kg, and 0.5 g/kg was observed. Fourteen days after drug treatment, platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid (AA), and collagen (COLL) was significantly reduced in rabbits of model group. Moreover,β‐thromboglobulin (β‐TG) level decreased obviously but no significant change in P‐selectin and platelet factor 4 (PF4) level, while QSYQ significantly decreased the ratio of thromboxane B2 (TXB2) to 6‐keto‐prostaglandin F1α(6‐Keto‐PGF1α) and increased cyclic adenosine monophosphate (cAMP) level in rabbits. In summary, QSYQ can improve platelets aggregation and inhibit the over‐release ofβ‐TG in hyperlipidemic rabbits; and the increased cAMP level may be involved in this process. These results suggest that the antiplatelet aggregation effect of QSYQ may be due to its ability to increase cAMP level for improving cAMP metabolism.
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DOI：
10.1016/s0735-1097(85)80552-0
发表时间：
1985-01-01
影响因子：
24
作者：
FUSTER, V;STEELE, PM;CHESEBRO, JH
通讯作者：
CHESEBRO, JH
影响因子：
5.7
作者：
Zhang, X-H;Lu, Z. L.;Liu, L.
通讯作者：
Liu, L.
影响因子：
10.4
作者：
Speich, H. E.;Earhart, A. D.;Jennings, L. K.
通讯作者：
Jennings, L. K.
影响因子：
46.9
作者：
Lehar, Joseph;Krueger, Andrew S.;Avery, William;Heilbut, Adrian M.;Johansen, Lisa M.;Price, E. Roydon;Rickles, Richard J.;Short, Glenn F., III;Staunton, Jane E.;Jin, Xiaowei;Lee, Margaret S.;Zimmermann, Grant R.;Borisy, Alexis A.
通讯作者：
Borisy, Alexis A.
DOI：
10.1038/sc.1994.84
发表时间：
1994-08-01
期刊：
PARAPLEGIA
影响因子：
--
作者：
MITSUHASHI, T;IKATA, T;KATOH, S
通讯作者：
KATOH, S