Metabolic cycles are linked to the cardiovascular diurnal rhythm in rats with essential hypertension.
Metabolic cycles are linked to the cardiovascular diurnal rhythm in rats with essential hypertension.
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DOI：
10.1371/journal.pone.0017339
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发表时间：
2011-02-22
期刊：
影响因子：
3.7
通讯作者：
Maeda M
中科院分区：
文献类型：
--
作者：
Cui H;Kohsaka A;Waki H;Bhuiyan ME;Gouraud SS;Maeda M
血压昼夜节律的丧失是高血压和糖尿病患者终末器官损伤的重要预测指标。最近的证据表明，代谢和心血管节律这两种主要的生理昼夜节律受到重叠的分子通路的调节，这表明代谢周期的失调可能会使血压的正常昼夜节律与日常的光/暗周期不同步。然而，代谢周期变化对血压昼夜节律的影响知之甚少。为了验证摄食-禁食周期可能影响血压昼夜模式的假设，我们以自发性高血压大鼠（SHR）为研究对象，观察其血压昼夜节律紊乱是否与日常摄食节律改变有关。我们发现SHR不仅在代谢组织中，而且在心血管组织中也表现出摄食节律减弱，并伴有代谢基因表达节律紊乱。更重要的是，SHR中异常摄食节律的纠正恢复了日常血压节律，并伴随着心血管组织中关键昼夜节律和代谢基因表达时间的改变。这些结果表明，代谢周期是心血管昼夜节律的重要决定因素，高血压患者的血压节律紊乱可以通过调节进食周期来正常化。
The loss of diurnal rhythm in blood pressure (BP) is an important predictor of end-organ damage in hypertensive and diabetic patients. Recent evidence has suggested that two major physiological circadian rhythms, the metabolic and cardiovascular rhythms, are subject to regulation by overlapping molecular pathways, indicating that dysregulation of metabolic cycles could desynchronize the normal diurnal rhythm of BP with the daily light/dark cycle. However, little is known about the impact of changes in metabolic cycles on BP diurnal rhythm. To test the hypothesis that feeding-fasting cycles could affect the diurnal pattern of BP, we used spontaneously hypertensive rats (SHR) which develop essential hypertension with disrupted diurnal BP rhythms and examined whether abnormal BP rhythms in SHR were caused by alteration in the daily feeding rhythm. We found that SHR exhibit attenuated feeding rhythm which accompanies disrupted rhythms in metabolic gene expression not only in metabolic tissues but also in cardiovascular tissues. More importantly, the correction of abnormal feeding rhythms in SHR restored the daily BP rhythm and was accompanied by changes in the timing of expression of key circadian and metabolic genes in cardiovascular tissues. These results indicate that the metabolic cycle is an important determinant of the cardiovascular diurnal rhythm and that disrupted BP rhythms in hypertensive patients can be normalized by manipulating feeding cycles.
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