A differentially amplified motion in the ear for near-threshold sound detection.
A differentially amplified motion in the ear for near-threshold sound detection.
复制标题
DOI：
10.1038/nn.2827
复制
发表时间：
2011-06
影响因子：
25
通讯作者：
Nuttall, Alfred L.
中科院分区：
文献类型：
--
作者：
Chen, Fangyi;Zha, Dingjun;Fridberger, Anders;Zheng, Jiefu;Choudhury, Niloy;Jacques, Steven L.;Wang, Ruikang K.;Shi, Xiaorui;Nuttall, Alfred L.
耳朵是一个非常灵敏的压力波动探测器。在豚鼠中，行为测量表明在16 kHz时可检测到的最小声压为~20 μPa。这种微弱的声音会产生0.1 nm的基底膜位移，这个距离比离子通道中的构象转变还要小。听觉系统中的噪音似乎会淹没这种微小的运动，使微弱的声音难以察觉。本文提出了一种有助于解决这一问题的新机制，并通过直接测量进行了验证。我们假设，与通常测量的基底膜侧相比，毛细胞顶端端的振动增强。使用体内光学相干断层扫描，我们证明了与基底膜相比，顶侧振动的峰值频率更高，时间不同，并且增强。这些效应非线性地依赖于刺激水平。时间差和增强对于解释如何规避噪声问题很重要。
The ear is a remarkably sensitive pressure fluctuation detector. In guinea pigs, behavioral measurements indicate a minimum detectable sound pressure of ~20 μPa at 16 kHz. Such faint sounds produce 0.1 nm basilar membrane displacements, a distance smaller than conformational transitions in ion channels. It seems that noise within the auditory system would swamp such tiny motions, making weak sounds imperceptible. Here, a new mechanism contributing to a resolution of this problem is proposed and validated through direct measurement. We hypothesize that vibration at the apical end of hair cells is enhanced compared to the commonly measured basilar membrane side. Using in vivo optical coherence tomography, we demonstrated that apical-side vibrations peak at a higher frequency, had different timing, and were enhanced compared to the basilar membrane. These effects depend nonlinearly on the stimulus level. The timing difference and enhancement are important for explaining how the noise problem is circumvented.
登录
查看更多内容
影响因子：
2.4
作者：
HEFFNER, R;HEFFNER, H;MASTERTON, B
通讯作者：
MASTERTON, B
影响因子：
5.3
作者：
Fridberger, A;de Monvel, JB;Nuttall, A
通讯作者：
Nuttall, A
DOI：
10.1073/pnas.0913657107
发表时间：
2010-05-04
影响因子：
11.1
作者：
Barral, Jeremie;Dierkes, Kai;Martin, Pascal
通讯作者：
Martin, Pascal
DOI：
10.1073/pnas.93.16.8727
发表时间：
1996-08-06
影响因子：
11.1
作者：
Gummer, AW;Hemmert, W;Zenner, HP
通讯作者：
Zenner, HP
影响因子：
2.4
作者：
ALLEN, JB
通讯作者：
ALLEN, JB