Factors associated with receipt of COVID-19 vaccination and SARS-CoV-2 seropositivity among healthcare workers in Albania (February 2021-June 2022): secondary analysis of a prospective cohort study.
Factors associated with receipt of COVID-19 vaccination and SARS-CoV-2 seropositivity among healthcare workers in Albania (February 2021-June 2022): secondary analysis of a prospective cohort study.
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DOI：
10.1016/j.lanepe.2023.100584
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发表时间：
2023-04
影响因子：
20.9
通讯作者：
Bino, Silvia
中科院分区：
文献类型：
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作者：
Jorgensen, Pernille;Schmid, Alexis;Sulo, Jonilda;Preza, Iria;Hasibra, Iris;Kissling, Esther;Fico, Albana;Sridhar, Shela;Rubin-Smith, Julia E.;Kota, Majlinda;Vasili, Adela;Daja, Rovena;Nika, Miljana;Pebody, Richard;Lafond, Kathryn E.;Katz, Mark A.;Bino, Silvia
医护人员受到COVID-19的严重影响。我们通过二次分析调查了阿尔巴尼亚前瞻性COVID-19疫苗有效性队列中招募的1504名HCW（2021年2月19日至5月7日）中与两剂和三剂COVID-19疫苗接种和SARS-CoV-2血清阳性相关的因素。我们收集了入组时所有医护人员的社会人口统计学、职业、健康、既往SARS-CoV-2感染和COVID-19疫苗接种数据。每周评估疫苗接种状况，直至2022年6月。在入组时从所有参与者中采集血清样本，并检测抗尖峰SARS-CoV-2抗体。我们使用多变量逻辑回归分析HCW的特征和结果。截至2022年6月11日，1337名（88.9%）医护人员已接种两剂COVID-19疫苗，其中255名（19.1%）接种了加强疫苗。与接受三次剂量显著相关的因素（调整的比值比（aOR），95% CI）≥35岁（35-44岁：1.76（1.05-2.97）; 45-54岁：3.11（1.92-5.05）; ≥55岁：3.38（2.04-5.59））和接种流感疫苗（1.78; 1.20-2.64）。女性（0.58; 0.41-0.81）、既往感染者（0.67; 0.48-0.93）、护士和助产士（0.31; 0.22-0.45）以及辅助人员（0.19; 0.11-0.32）接受加强剂量较低。总体而言，1076例（72%）患者在入组时为SARS-CoV-2血清阳性。护士和助产士（1.45; 1.05-2.02）、辅助人员（1.57; 1.03-2.41）和执行气溶胶生成程序（AGPs）的医护人员（1.40; 1.01-1.94）的血清阳性几率较高，而吸烟者的几率较低（0.55; 0.40-0.75）。在阿尔巴尼亚HCW的一个大型队列中，COVID-19疫苗加强剂的摄入量非常低，特别是在年轻，女性和非医生HCW中，尽管有证据表明加强剂在预防感染和严重疾病方面具有额外的益处。应探讨这些差异背后的原因，以制定有针对性的战略，促进这一关键人群的接受。SARS-CoV-2血清阳性率在非医生和从事APG的医务人员中较高。需要更好地了解导致这些差异的因素，以便为未来可能减少感染的干预措施提供信息。本研究由（（CDC）合作协议编号NU 51 IP 000873）工作组和欧洲区域办事处资助。
Healthcare workers (HCWs) have been disproportionally affected by COVID-19. We investigated factors associated with two- and three-dose COVID-19 vaccine uptake and SARS-CoV-2 seropositivity among 1504 HCWs enrolled (19 February-7 May 2021) in a prospective COVID-19 vaccine effectiveness cohort in Albania through a secondary analysis. We collected sociodemographic, occupational, health, prior SARS-CoV-2 infection, and COVID-19 vaccination data from all HCWs at enrollment. Vaccination status was assessed weekly through June 2022. A serum sample was collected from all participants at enrollment and tested for anti-spike SARS-CoV-2 antibodies. We analyzed HCWs characteristics and outcomes using multivariable logistic regression. By 11 June 2022, 1337 (88.9%) HCWs had received two COVID-19 vaccine doses, of whom 255 (19.1%) received a booster. Factors significantly associated with receiving three doses (adjusted odds ratio (aOR), 95% CIs) were being ≥35 years (35–44 years: 1.76 (1.05–2.97); 45–54 years: 3.11 (1.92–5.05); ≥55 years: 3.38 (2.04–5.59)) and vaccinated against influenza (1.78; 1.20–2.64). Booster dose receipt was lower among females (0.58; 0.41–0.81), previously infected (0.67; 0.48–0.93), nurses and midwives (0.31; 0.22–0.45), and support staff (0.19; 0.11–0.32). Overall 1076 (72%) were SARS-CoV-2 seropositive at enrollment. Nurses and midwifes (1.45; 1.05–2.02), support staff (1.57; 1.03–2.41), and HCWs performing aerosol-generating procedures (AGPs) (1.40; 1.01–1.94) had higher odds of being seropositive, while smokers had reduced odds (0.55; 0.40–0.75). In a large cohort of Albanian HCWs, COVID-19 vaccine booster dose uptake was very low, particularly among younger, female, and non-physician HCWs, despite evidence demonstrating the added benefit of boosters in preventing infection and severe disease. Reasons behind these disparities should be explored to develop targeted strategies in order to promote uptake in this critical population. SARS-CoV-2 seroprevalence was higher among non-physicians and HCWs performing APGs. A better understanding of the factors contributing to these differences is needed to inform interventions that could reduce infections in the future. This study was funded by the Task Force for ( (CDC) cooperative agreement # NU51IP000873) and the , Regional Office for Europe.
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影响因子：
2.9
作者：
Sridhar S;Fico A;Preza I;Hatibi I;Sulo J;Kissling E;Daja R;Ibrahim R;Lemos D;Rubin-Smith J;Schmid A;Vasili A;Valenciano M;Jorgensen P;Pebody R;Lafond KE;Katz MA;Bino S
通讯作者：
Bino S
影响因子：
15.8
作者：
通讯作者：
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DOI：
10.1016/j.cmi.2021.05.036
发表时间：
2021-09
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
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作者：
Kayı İ;Madran B;Keske Ş;Karanfil Ö;Arribas JR;Psheniсhnaya N;Petrosillo N;Gönen M;Ergönül Ö
通讯作者：
Ergönül Ö
影响因子：
16.6
作者：
GeurtsvanKessel, Corine H.;Okba, Nisreen M. A.;Koopmans, Marion
通讯作者：
Koopmans, Marion
DOI：
10.1056/nejmoa2203965
发表时间：
2022-07-07
期刊：
The New England journal of medicine
影响因子：
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作者：
通讯作者：
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