The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis.
The seroprevalence of SARS-CoV-2 antibodies among health care workers before the era of vaccination: a systematic review and meta-analysis.
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DOI：
10.1016/j.cmi.2021.05.036
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Ergönül Ö
中科院分区：
文献类型：
--
作者：
Kayı İ;Madran B;Keske Ş;Karanfil Ö;Arribas JR;Psheniсhnaya N;Petrosillo N;Gönen M;Ergönül Ö
SARS-CoV-2感染在卫生保健工作者（HCW）中的流行率提供了有关COVID-19在卫生保健设施和风险群体中传播的信息。我们的目的是描述在医护人员中SARS-CoV-2血清阳性率及其决定因素。我们使用了Web of Science、PubMed、Scopus、MEDLINE、EBSCOhost和科克伦图书馆。我们纳入了SARS-CoV-2血清阳性报告，样本量至少为1000名HCW。该研究在国际前瞻性系统评价注册中心（PROSPERO，编号CRD 42021230456）注册。我们使用PRISMA（系统性综述和荟萃分析的首选报告项目）声明。关键词为“COVID-19”、“SARS-CoV-2”、“冠状病毒”、“血清阳性率”、“医护人员”和“风险因素”。共检索到4329篇报告，删除重复;根据标题和摘要筛选后，选择了25项研究。在25项研究中评估了偏倚风险; 13项研究中偏倚风险较低，4项研究中偏倚风险中等，8项研究偏倚风险较高。在使用随机效应模型的荟萃分析中，血清阳性率的加权平均值计算为8%（95%CI 6-10%）。所选变量的合并血清阳性率高于平均值，男性HCW为9%（95% CI 7-11%）;少数民族HCW为13%（95% CI 9-17%）;高暴露9%（95% CI 6-13%）;在卫生保健环境外暴露于病毒为22%（95% CI 14-32%）。我们的分析表明，在疫苗接种开始前，在2020年包括超过1000名HCW的研究中，SARS-CoV-2血清阳性率为8%。与血清阳性率较高相关的最常见危险因素是种族、男性和有较多的家庭接触者。作为一线HCW工作与较高血清阳性率的相关性不一致。
The prevalence of SARS-CoV-2 infection among health care workers (HCWs) provides information about the spread of COVID-19 within health care facilities, and the risk groups. We aimed to describe the rate of SARS-CoV-2 seroprevalence and its determinants among HCWs. We used Web of Science, PubMed, Scopus, MEDLINE, EBSCOhost and Cochrane Library. We included the reports of SARS-CoV-2 seroprevalence with a sample size of minimum 1000 HCWs. The study was registered at the International Prospective Register of Systematic Reviews (PROSPERO, no. CRD42021230456). We used PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. The keywords were “COVID-19”, “SARS-CoV-2”, “Coronavirus”, “seroprevalence”, “health care workers” and “risk factors”. In total 4329 reports were retrieved, duplications were removed; after filtering according to the title and abstract, 25 studies were selected. Risk of bias was assessed in 25 studies; it was low in 13 studies, medium in four studies, and high in eight studies. In meta-analysis using the random effect model, the weighted average of seroprevalence was calculated as 8% (95% CI 6–10%). The pooled seroprevalence rates of the selected variables that have a rate above the average were male HCWs with 9% (95% CI 7–11%); HCWs from ethnic minorities with 13% (95% CI 9–17%); high exposure 9% (95% CI 6–13%); exposure to the virus outside the health care setting 22% (95% CI 14–32%). Our analysis indicates a SARS-CoV-2 seroprevalence rate of 8% among studies that included >1000 HCWs for the year 2020, before vaccinations started. The most common risk factors associated with higher seroprevalence rate were ethnicity, male gender and having a higher number of household contacts. Working as a frontline HCW was inconsistent in its association with higher seroprevalence.
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影响因子：
3.4
作者：
Lidström AK;Sund F;Albinsson B;Lindbäck J;Westman G
通讯作者：
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影响因子：
4.5
作者：
Dimcheff DE;Schildhouse RJ;Hausman MS;Vincent BM;Markovitz E;Chensue SW;Deng J;McLeod M;Hagan D;Russell J;Bradley SF
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冠状病毒病的性别差异（Covid-19）：系统评价和荟萃分析。
影响因子：
2.9
作者：
Abate BB;Kassie AM;Kassaw MW;Aragie TG;Masresha SA
通讯作者：
Masresha SA
DOI：
10.1016/j.ijid.2021.01.013
发表时间：
2021-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Gholami M;Fawad I;Shadan S;Rowaiee R;Ghanem H;Hassan Khamis A;Ho SB
通讯作者：
Ho SB