Condensational growth of combination drug-excipient submicrometer particles for targeted high-efficiency pulmonary delivery: evaluation of formulation and delivery device.
Condensational growth of combination drug-excipient submicrometer particles for targeted high-efficiency pulmonary delivery: evaluation of formulation and delivery device.
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DOI：
10.1111/j.2042-7158.2012.01476.x
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Longest PW
中科院分区：
文献类型：
--
作者：
Hindle M;Longest PW
本研究的目的是研究由一系列制剂和两种气雾剂输送装置产生的组合药物和赋形剂亚微米气雾剂的体外粒径增长。使用毛细管气雾发生器和 Respimat 吸入器通过实验产生亚微米组合药物和赋形剂颗粒。以布地奈德和硫酸沙丁胺醇为模型药物，以氯化钠、柠檬酸、甘露醇为赋形剂按不同比例配制而成。在设计用于提供与气道一致的停留时间和热力学条件的盘绕管几何形状中体外评估气溶胶生长。亚微米组合药物：当暴露于模拟呼吸条件时，赋形剂气雾剂增加至适合肺部沉积的微米尺寸。可以通过改变：(1)吸湿性赋形剂，(2)药物：赋形剂比率和(3)药物来控制气溶胶增长比率。使用毛细管气溶胶发生器和 Respimat 吸入器证明了该方法的适用性。增强赋形剂生长（EEG）方法可以实现亚微米气溶胶颗粒的输送，这些颗粒在气道内尺寸增加并导致高百分比的肺部沉积。
The objective of this study was to investigate the in vitro particle size growth of combination drug and excipient submicrometer aerosols generated from a series of formulations and two aerosol delivery devices. Submicrometer combination drug and excipient particles were generated experimentally using both the capillary aerosol generator and the Respimat inhaler. Budesonide and albuterol sulfate were used as model drugs and were formulated with sodium chloride, citric acid, and mannitol as excipients in various ratios. Aerosol growth was evaluated in vitro in a coiled tube geometry designed to provide residence times and thermodynamic conditions consistent with the airways. Submicrometer combination drug:excipient aerosols when exposed to simulated respiratory conditions increased to micrometer size suitable for pulmonary deposition. It was possible to control the aerosol growth ratio by altering: (1) the hygroscopic excipient, (2) the drug:excipient ratio and (3) the drug. The applicability of this approach was demonstrated using the capillary aerosol generator and the Respimat inhaler. The enhanced excipient growth (EEG) approach may enable the delivery of submicrometer aerosol particles that increase in size within the airways and result in high percentages of pulmonary deposition.
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影响因子：
4.5
作者：
Longest, P. Worth;Hindle, Michael
通讯作者：
Hindle, Michael
DOI：
10.1089/jamp.2008.0708
发表时间：
2009-06-01
影响因子：
3.4
作者：
Longest, P. Worth;Hindle, Michael
通讯作者：
Hindle, Michael
影响因子：
2
作者：
THUDIUM, J
通讯作者：
THUDIUM, J
DOI：
10.1089/jam.1999.12.suppl_1.s-19
发表时间：
1999-01-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Zierenberg, B
通讯作者：
Zierenberg, B
DOI：
10.1080/02786821003749525
发表时间：
2010-06-01
期刊：
Aerosol science and technology : the journal of the American Association for Aerosol Research
影响因子：
--
作者：
Longest PW;McLeskey JT Jr;Hindle M
通讯作者：
Hindle M