Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth.
Characterization of Nanoaerosol Size Change During Enhanced Condensational Growth.
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DOI：
10.1080/02786821003749525
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Hindle M
中科院分区：
文献类型：
--
作者：
Longest PW;McLeskey JT Jr;Hindle M
增加纳米气溶胶的尺寸在许多应用中可能是有益的，包括过滤、粒度选择和靶向呼吸药物递送。增加颗粒或液滴尺寸的潜在方法是增强冷凝生长（ECG），其涉及将气溶胶与饱和或过饱和空气组合。在这项研究中，我们的特征的ECG过程中的模型管状几何形状作为一个功能的初始气溶胶的大小（平均直径-150，560和900 nm）和相对湿度的条件下，使用在体外实验和数值模拟。评价了相对湿度（99.8 - 104%）和温度（25 - 39 °C），可安全地应用于靶向呼吸药物递送或个人气雾剂过滤系统。对于高于环境条件（30和39 °C）的入口饱和空气温度，初始纳米气溶胶在0.2秒的时间内增长到1000 - 3000 nm（1 - 3 μm）的尺寸范围。数值模型的结果与实验结果基本一致，并预测在0.2 s的湿度暴露后，最终与初始直径比高达8，在1 s时为14。基于这些观察结果，提出了一种呼吸系统药物递送方法，其中将尺寸范围为500 nm的纳米气溶胶与饱和或过饱和气流一起递送。初始纳米气溶胶尺寸将确保在口-喉区域中的最小沉积和损失，而呼吸道中的冷凝生长可用于确保最大的肺滞留并潜在地靶向沉积部位。
Increasing the size of nanoaerosols may be beneficial in a number of applications including filtration, particle size selection, and targeted respiratory drug delivery. A potential method to increase particle or droplet size is enhanced condensational growth (ECG), which involves combining the aerosol with saturated or supersaturated air. In this study, we characterize the ECG process in a model tubular geometry as a function of initial aerosol size (mean diameters – 150, 560 and 900 nm) and relative humidity conditions using both in vitro experiments and numerical modeling. Relative humidities (99.8 – 104%) and temperatures (25 – 39 °C) were evaluated that can safely be applied to either targeted respiratory drug delivery or personal aerosol filtration systems. For inlet saturated air temperatures above ambient conditions (30 and 39 °C), the initial nanoaerosols grew to a size range of 1000 – 3000 nm (1 – 3 μm) over a time period of 0.2 seconds. The numerical model results were generally consistent with the experimental findings and predicted final to initial diameter ratios of up to 8 after 0.2 s of humidity exposure and 14 at 1 s. Based on these observations, a respiratory drug delivery approach is suggested in which nanoaerosols in the size range of 500 nm are delivered in conjunction with a saturated or supersaturated air stream. The initial nanoaerosol size will ensure minimal deposition and loss in the mouth-throat region while condensational growth in the respiratory tract can be used to ensure maximal lung retention and to potentially target the site of deposition.
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影响因子：
4.5
作者：
HEYDER, J;GEBHART, J;STAHLHOFEN, W
通讯作者：
STAHLHOFEN, W
DOI：
10.1089/jam.2006.19.473
发表时间：
2006-12-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Borgstrom, Lars;Olsson, Bo;Thorsson, Lars
通讯作者：
Thorsson, Lars
影响因子：
24.3
作者：
Leach, CL;Davidson, PJ;Boudreau, RJ
通讯作者：
Boudreau, RJ
DOI：
10.1089/jam.2006.19.74
发表时间：
2006-03-01
期刊：
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG
影响因子：
--
作者：
Kreyling, WG;Semmler-Behnke, M;Möller, W
通讯作者：
Möller, W
影响因子：
5.2
作者：
Cheng, YS
通讯作者：
Cheng, YS