Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice.
Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice.
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DOI：
10.18632/oncotarget.461
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Sánchez-García I
中科院分区：
文献类型：
--
作者：
Vicente-Dueñas C;Barajas-Diego M;Romero-Camarero I;González-Herrero I;Flores T;Sánchez-García I
端粒酶蛋白在包括慢性髓性白血病（CML）在内的许多癌症患者的恶性细胞中被组成性激活，但端粒酶是否是这种疾病的发病机制所必需的尚不清楚。在这里，我们使用端粒酶缺陷小鼠，以确定在CML的小鼠模型中，由BCR-ABL诱导的CML对端粒酶的需求。BCR-ABL在端粒酶杂合型和缺失型白血病造血干细胞中均有表达和活性，但BCR-ABL在端粒酶杂合型和缺失型白血病造血干细胞中均有表达和活性。这些结果表明，端粒酶是必不可少的癌基因诱导的造血干细胞在CML的发展和验证端粒酶和基因调控的治疗CML的目标。
The telomerase protein is constitutively activated in malignant cells from many patients with cancer, including the chronic myeloid leukemia (CML), but whether telomerase is essential for the pathogenesis of this disease is not known. Here, we used telomerase deficient mice to determine the requirement for telomerase in CML induced by BCR-ABL in mouse models of CML. Loss of one telomerase allele or complete deletion of telomerase prevented the development of leukemia induced by BCR-ABL. However, BCR-ABL was expressed and active in telomerase heterozygous and null leukemic hematopoietic stem cells. These results demonstrate that telomerase is essential for oncogene-induced reprogramming of hematopoietic stem cells in CML development and validate telomerase and the genes it regulates as targets for therapy in CML.
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影响因子：
8
作者：
Perez-Caro, M.;Gutierrez-Cianca, N.;Sanchez-Garcia, I.
通讯作者：
Sanchez-Garcia, I.
影响因子：
4.3
作者：
Vicente-Duenas, Carolina;Perez-Caro, Maria;Sanchez-Garcia, Isidro
通讯作者：
Sanchez-Garcia, Isidro
影响因子：
64.8
作者：
Lee, HW;Blasco, MA;DePinho, RA
通讯作者：
DePinho, RA
影响因子：
50.3
作者：
Feldser, David M.;Greider, Carol W.
通讯作者：
Greider, Carol W.
影响因子：
64.8
作者：
HARLEY, CB;FUTCHER, AB;GREIDER, CW
通讯作者：
GREIDER, CW