Prolactin‐Releasing Peptide Regulates the Cardiovascular System Via Corticotrophin‐Releasing Hormone
Prolactin‐Releasing Peptide Regulates the Cardiovascular System Via Corticotrophin‐Releasing Hormone
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催乳素释放肽通过促肾上腺皮质激素释放激素调节心血管系统
DOI：
10.1111/j.1365-2826.2009.01875.x
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发表时间：
2009
影响因子：
3.2
通讯作者：
K. Inoue
中科院分区：
文献类型：
--
作者：
T. Yamada;A. Mochiduki;Y. Sugimoto;Y. Suzuki;K. Itoi;K. Inoue
已知产生催乳素释放肽（PrRP）的神经元主要位于延髓，并在中枢神经系统中充当应激介质。此外，中央给药PrRP可提高动脉压和心率。然而，PrRP对心血管作用的神经通路尚未揭示。在本研究中，我们发现PrRP‐免疫反应神经元投射到下丘脑蓝斑核（LC）和室旁核（PVN）。中央给药PrRP后，LC中去甲肾上腺素细胞中的c - fos阳性神经元以及PVN中的小细胞和大细胞神经元数量增加。静脉注射PrRP后动脉压和心率均升高。先前的研究表明，PrRP刺激PVN中的神经元[即催产素-，抗利尿激素-和促肾上腺皮质激素释放激素(CRH) -产生神经元]，这表明PrRP可能通过精氨酸抗利尿激素（AVP）或CRH诱导其心血管作用。虽然PrRP引起的血压和心率升高没有被AVP拮抗剂抑制，但它们被CRH拮抗剂完全抑制。因此，我们得出结论，PrRP刺激PVN中的CRH神经元，CRH可能通过交感神经系统调节心血管系统。
Prolactin‐releasing peptide (PrRP)‐producing neurones are known to be localised mainly in the medulla oblongata and to act as a stress mediator in the central nervous system. In addition, central administration of PrRP elevates the arterial pressure and heart rate. However, the neuronal pathway of the cardiovascular effects of PrRP has not been revealed. In the present study, we demonstrate that PrRP‐immunoreactive neurones projected to the locus coeruleus (LC) and the paraventricular nucleus (PVN) of the hypothalamus. The c‐fos positive neurones among the noradrenaline cells in the LC, and the parvo‐ and magnocellular neurones in the PVN, were increased after central administration of PrRP. The arterial pressure and heart rate were both elevated after i.c.v. administration of PrRP. Previous studies have demonstrated that PrRP stimulated the neurones in the PVN [i.e. oxytocin‐, vasopressin‐ and corticotrophin‐releasing hormone (CRH)‐producing neurones], which suggests that PrRP may induce its cardiovascular effect via arginine vasopressin (AVP) or CRH. Although the elevation of blood pressure and heart rate elicited by PrRP administration were not inhibited by an AVP antagonist, they were completely suppressed by treatment with a CRH antagonist. Thus, we conclude that PrRP stimulated CRH neurones in the PVN and that CRH might regulate the cardiovascular system via the sympathetic nervous system.
影响因子：
--
作者：
E. Ronald;D. Kloet
通讯作者：
E. Ronald;D. Kloet
促肾上腺皮质激素释放因子的化学和生物学特征。
DOI：
10.1016/b978-0-12-571139-5.50010-0
发表时间：
1983
期刊：
Recent progress in hormone research
影响因子：
--
作者：
Vale,W;Rivier,C;Brown,MR;Spiess,J;Koob,G;Swanson,L;Bilezikjian,L;Bloom,F;Rivier,J
通讯作者：
Rivier,J