Select cognitive deficits in vasoactive intestinal peptide deficient mice.
Select cognitive deficits in vasoactive intestinal peptide deficient mice.
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DOI：
10.1186/1471-2202-9-63
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发表时间：
2008-07-10
期刊：
影响因子：
2.4
通讯作者：
Colwell, Christopher S.
中科院分区：
文献类型：
--
作者：
Chaudhury, Dipesh;Loh, Dawn H.;Dragich, Joanna M.;Hagopian, Arkady;Colwell, Christopher S.
神经肽血管活性肠肽（VIP）广泛分布于成人中枢神经系统，其功能是调节突触传递和神经兴奋性。VIP及其受体在参与学习和记忆功能的脑区（包括海马、皮质和杏仁核）中的表达提高了这种肽可能起调节学习行为的作用的可能性。在其他行动中，VIP的损失对昼夜节律时间有深远的影响，并可能特别影响学习和记忆功能的时间调节。在本研究中，我们利用转基因VIP缺陷小鼠和情境恐惧条件反射范式，探讨这种肽的损失对学习行为的影响。我们发现VIP缺陷小鼠表现出正常的休克诱发的冻结行为和皮质酮的增加。同样，这些突变小鼠在训练24小时后进行测试时，在获得或回忆恐惧条件行为方面没有表现出缺陷。VIP缺陷小鼠在训练后48小时或更长时间进行测试时，回忆率显着降低。令人惊讶的是，我们发现VIP缺乏的小鼠在回忆训练时继续表达昼夜节律，即使在那些转轮活动是间歇性的小鼠中也是如此。一种机制解释是，在VIP缺陷小鼠的海马中，时钟基因Period2表达的每日节律持续存在。总之，这些数据表明，神经肽VIP调节至少一个学习行为的回忆，但不影响这种行为的昼夜节律调节。
The neuropeptide vasoactive intestinal peptide (VIP) is widely distributed in the adult central nervous system where this peptide functions to regulate synaptic transmission and neural excitability. The expression of VIP and its receptors in brain regions implicated in learning and memory functions, including the hippocampus, cortex, and amygdala, raise the possibility that this peptide may function to modulate learned behaviors. Among other actions, the loss of VIP has a profound effect on circadian timing and may specifically influence the temporal regulation of learning and memory functions. In the present study, we utilized transgenic VIP-deficient mice and the contextual fear conditioning paradigm to explore the impact of the loss of this peptide on a learned behavior. We found that VIP-deficient mice exhibited normal shock-evoked freezing behavior and increases in corticosterone. Similarly, these mutant mice exhibited no deficits in the acquisition or recall of the fear-conditioned behavior when tested 24-hours after training. The VIP-deficient mice exhibited a significant reduction in recall when tested 48-hours or longer after training. Surprisingly, we found that the VIP-deficient mice continued to express circadian rhythms in the recall of the training even in those individual mice whose wheel running wheel activity was arrhythmic. One mechanistic explanation is suggested by the finding that daily rhythms in the expression of the clock gene Period2 continue in the hippocampus of VIP-deficient mice. Together these data suggest that the neuropeptide VIP regulates the recall of at least one learned behavior but does not impact the circadian regulation of this behavior.
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影响因子：
12.3
作者：
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影响因子：
2.9
作者：
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发表时间：
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通讯作者：
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影响因子：
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作者：
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