Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.
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血管紧张素转换酶（ACE）基因插入/缺失多态性和ACE抑制剂相关的咳嗽：荟萃分析。
DOI：
10.1371/journal.pone.0037396
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yang XC
中科院分区：
文献类型：
--
作者：
Li YF;Zhu XM;Liu F;Xiao CS;Bian YF;Li H;Cai J;Li RS;Yang XC
在先前的研究中，血管紧张素转换酶（ACE）基因的插入/缺失（I/D）变异与ACE抑制剂（ACEI）相关的咳嗽有关。然而，结果并不一致。我们的目的是通过荟萃分析评估ACEI /D多态性与acei相关性咳嗽的关系，并总结所有与ACEI /D多态性与acei相关性咳嗽相关的研究，得出总结结论，为尝试进行此类研究的研究者提供参考。检索了PubMed、EMbase、Cochrane Library和中国国家知识基础设施等数据库进行遗传关联研究。数据由两位独立作者提取，计算合并优势比（OR）和95%可信区间（CI）。采用元回归和亚组分析来确定异质性的来源。本荟萃分析回顾了11项试验，包括906例（acei相关咳嗽）和1175例对照。显性模型的随机效应合并OR为1.16 (95%CI: 0.78 ~ 1.74, p = 0.46)，隐性模型的随机效应合并OR为1.61 （95%CI: 1.18 ~ 2.20, p = 0.003）。研究之间和研究内部均存在异质性。回归分析表明，效应量与年龄呈正相关，与ACEI治疗随访时间负相关。亚组分析显示，在平均年龄为60岁的研究中，ACEI /D多态性与acei相关咳嗽之间存在显著相关性，而在平均年龄≤60岁的研究中则无显著相关性。每个平均年龄亚组内均未发现异质性。我们还发现，在随访20 ~ 20个月的研究中或在白种人研究中，ACEI /D多态性与acei相关的咳嗽之间没有关联。在这两个亚组中未发现异质性。综合现有证据支持ACEI /D多态性作为acei相关咳嗽风险的年龄依赖性预测因子。
An insertion/deletion (I/D) variant in the angiotensin-converting enzyme (ACE) gene was associated with ACE inhibitor (ACEI)–related cough in previous studies. However, the results were inconsistent. Our objective was to assess the relationship between the ACE I/D polymorphism and ACEI-related cough by meta-analysis and to summarize all studies that are related to ACE I/D polymorphism and ACEI-cough and make a summary conclusion to provide reference for the researchers who attempt to conduct such a study. Databases including PubMed, EMbase, Cochrane Library, and China National Knowledge Infrastructure, were searched for genetic association studies. Data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Metaregression and subgroup analyses were performed to identify the source of heterogeneity. Eleven trials, including 906 cases (ACEI-related cough) and 1,175 controls, were reviewed in the present meta-analysis. The random effects pooled OR was 1.16 (95%CI: 0.78–1.74, p = 0.46) in the dominant model and 1.61 (95%CI: 1.18–2.20, p = 0.003) in the recessive model. Heterogeneity was found among and within studies. Metaregression indicated that the effect size was positively associated with age and negatively associated with follow-up duration of ACEI treatment. Subgroup analysis revealed a significant association between ACE I/D polymorphism and ACEI-related cough in studies with mean age >60 y, but not in studies with mean age ≤60 y. No heterogeneity was found within each mean age subgroup. We also found no association between ACE I/D polymorphism and ACEI-related cough in studies with follow-up>2 mo or in studies in Caucasians. No heterogeneity was detected in these two subgroups. Synthesis of the available evidence supports ACE I/D polymorphism as an age-dependent predictor for risk of ACEI-related cough.
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影响因子：
158.5
作者：
PFEFFER, MA;BRAUNWALD, E;HAWKINS, CM
通讯作者：
HAWKINS, CM
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
3.2
作者：
Okaishi, K;Morimoto, S;Ogihara, T
通讯作者：
Ogihara, T
DOI：
10.1006/bbrc.1995.1845
发表时间：
1995-06-15
影响因子：
3.1
作者：
JASPARD, E;ALHENCGELAS, F
通讯作者：
ALHENCGELAS, F
影响因子：
10
作者：
Morice, AH;Turley, AJ;Linton, K
通讯作者：
Linton, K