MicroRNA-122 in human cancers: from mechanistic to clinical perspectives.
MicroRNA-122 in human cancers: from mechanistic to clinical perspectives.
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DOI：
10.1186/s12935-023-02868-z
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发表时间：
2023-02-20
影响因子：
5.8
通讯作者：
中科院分区：
文献类型：
--
作者：
microRNA（miRNAs）是一类内源性短链非编码RNA，可在转录后调节靶基因的表达，并与mRNA编码基因相互作用。miRNA在许多生物学功能中起着重要作用，异常的miRNA表达与包括癌症在内的各种疾病有关。在miRNA中，miR-122、miR-206、miR-21、miR-210、miR-223和miR-424已在各种癌症中被广泛研究。尽管在过去的十年中，miRNA的研究有了很大的发展，但还有很多东西有待发现，特别是关于它们在癌症治疗中的作用。几种癌症与miR-122的失调和异常表达有关，表明miR-122可以作为人类癌症的诊断和/或预后生物标志物。因此，在这篇综述文献中，已经在许多癌症类型中分析了miR-122，以筛选出癌细胞miR-122的功能并增强患者对标准治疗的反应。
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.
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影响因子：
11.1
作者：
Cheng D;Deng J;Zhang B;He X;Meng Z;Li G;Ye H;Zheng S;Wei L;Deng X;Chen R;Zhou J
通讯作者：
Zhou J
血浆 miR-122 和 miR-192 作为早期检测胃癌远处转移的潜在新型生物标志物。
影响因子：
4.2
作者：
Chen, Qingjuan;Ge, Xiaojun;Bi, Feng
通讯作者：
Bi, Feng
影响因子：
2.6
作者：
Ding, Feng-Na;Gao, Bao-Hong;Zhang, Shu-Mao
通讯作者：
Zhang, Shu-Mao
影响因子：
3.9
作者：
Duan, Yanan;Dong, Yinghui;Cheng, Jianxin
通讯作者：
Cheng, Jianxin
影响因子：
2.8
作者：
Ergun, Sercan;Ulasli, Mustafa;Oztuzcu, Serdar
通讯作者：
Oztuzcu, Serdar