Differential regulation of EGFR-MAPK signaling by deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) in colon cancer.
Differential regulation of EGFR-MAPK signaling by deoxycholic acid (DCA) and ursodeoxycholic acid (UDCA) in colon cancer.
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DOI：
10.1007/s10620-014-3190-7
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发表时间：
2014-10
影响因子：
3.1
通讯作者：
Martinez, Jesse D.
中科院分区：
文献类型：
--
作者：
Centuori, Sara M.;Martinez, Jesse D.
关键词：
高脂肪饮食与胆汁酸水平升高不谋而合。胆汁酸的这种升高，特别是脱氧胆酸(DCA)，与结肠癌的发生密切相关。相反，熊去氧胆酸(UDCA)可能具有化学预防特性。尽管DCA和UDCA在结构上相似，但它们在结肠癌进展过程中表现出不同的生物学和病理学效应。这两种胆汁酸对癌症的不同调控尚不完全清楚。然而，它们的不同作用的一个可能的解释是它们能够不同地调节参与结肠癌多步进展的信号通路，例如表皮生长因子受体(EGFR)有丝分裂原激活的蛋白激酶(MAPK)通路。该综述将探讨DCA和UDCA在结肠癌发生中的生物学作用，以及这些胆汁酸对在结肠癌发生中起作用的致癌信号通路的不同作用，特别是胆汁酸对EGFR-MAPK通路的调节。
A high fat diet coincides with elevated levels of bile acids. This elevation of bile acids, particularly deoxycholic acid (DCA), has been strongly associated with the development of colon cancer. Conversely, ursodeoxycholic acid (UDCA) may have chemopreventive properties. Although structurally similar, DCA and UDCA present different biological and pathological effects in colon cancer progression. The differential regulation of cancer by these two bile acids is not yet fully understood. However, one possible explanation for their diverging effects is their ability to differentially regulate signaling pathways involved in the multistep progression of colon cancer, such as the epidermal growth factor receptor (EGFR) mitogen-activated protein kinase (MAPK) pathway. This review will examine the biological effects of DCA and UDCA on colon cancer development, as well as the diverging effects of these bile acids on the oncogenic signaling pathways that play a role in colon cancer development, with a particular emphasis on bile acid regulation of the EGFR-MAPK pathway.
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