A portable, programmable, multichannel stimulator with high compliance voltage for noninvasive neural stimulation of motor and sensory nerves in humans.
A portable, programmable, multichannel stimulator with high compliance voltage for noninvasive neural stimulation of motor and sensory nerves in humans.
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DOI：
10.1038/s41598-023-30545-8
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发表时间：
2023-03-01
影响因子：
4.6
通讯作者：
George, Jacob A.
中科院分区：
文献类型：
--
作者：
Trout, Marshall A.;Harrison, Abigail T.;Brinton, Mark R.;George, Jacob A.
大多数神经刺激器没有足够高的顺应电压使电流通过皮肤。少数满足经皮刺激所需的高顺应电压的刺激器通常是大型台式装置，不便于携带，并且刺激波形不能轻易定制。为了解决这个问题，我们提出了一种便携式、可编程、多通道、无创神经刺激器的设计和验证，该神经刺激器可以在±150 V下产生三个定制的双极波形，时间分辨率为微秒。该设计是低成本的，开源的，并在台式和健康人群中验证，以展示其感官和运动刺激的功能。感觉刺激包括针对皮肤表面的皮肤机械感受器的皮电刺激和针对手腕正中神经的经皮神经刺激。手部的皮电刺激和手腕的经皮刺激都能引起手部孤立的触觉知觉，但皮电刺激的脉冲频率变化更容易辨别。此外，通过对前臂肌肉上方和上臂的正中神经和尺神经施加电刺激，可以引起指深屈肌的神经肌肉电刺激。肌肉和神经刺激引起的握力和力上升时间相似，但神经刺激的疲劳率明显较慢。这种无创刺激器的开发和验证，以及在人群中直接比较常见的感觉和运动刺激目标，是朝着更广泛地使用和获得神经刺激的教育和研究迈出的重要一步。
Most neural stimulators do not have a high enough compliance voltage to pass current through the skin. The few stimulators that meet the high compliance voltage necessary for transcutaneous stimulation are typically large benchtop units that are not portable, and the stimulation waveforms cannot be readily customized. To address this, we present the design and validation of a portable, programmable, multichannel, noninvasive neural stimulator that can generate three custom bipolar waveforms at ± 150 V with microsecond temporal resolution. The design is low-cost, open-source, and validated on the benchtop and with a healthy population to demonstrate its functionality for sensory and motor stimulation. Sensory stimulation included electrocutaneous stimulation targeting cutaneous mechanoreceptors at the surface of the skin and transcutaneous nerve stimulation targeting the median nerve at the wrist. Both electrocutaneous stimulation on the hand and transcutaneous stimulation at the wrist can elicit isolated tactile percepts on the hand but changes in pulse frequency are more discriminable for electrocutaneous stimulation. Also, neuromuscular electrical stimulation of the flexor digiti profundus is evoked by applying electrical stimulation directly above the muscle in the forearm and to the median and ulnar nerves in the upper arm. Muscle and nerve stimulation evoked similar grip forces and force rise times, but nerve stimulation had a significantly slower fatigue rate. The development and validation of this noninvasive stimulator and direct comparison of common sensory and motor stimulation targets in a human population constitute an important step towards more widespread use and accessibility of neural stimulation for education and research.
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影响因子：
17.1
作者：
Graczyk EL;Schiefer MA;Saal HP;Delhaye BP;Bensmaia SJ;Tyler DJ
通讯作者：
Tyler DJ
影响因子：
4.6
作者：
Annetta, Nicholas V.;Friend, Jeffrey;Sharma, Gaurav
通讯作者：
Sharma, Gaurav
DOI：
10.1109/tbcas.2021.3107723
发表时间：
2021-10-01
影响因子：
5.1
作者：
Abbass, Yahya;Saleh, Moustafa;Valle, Maurizio
通讯作者：
Valle, Maurizio
影响因子：
2.9
作者：
Dideriksen, Jakob;Markovic, Marko;Dosen, Strahinja
通讯作者：
Dosen, Strahinja
影响因子：
4
作者：
Garenfeld, Martin A.;Mortensen, Christian K.;Dosen, Strahinja
通讯作者：
Dosen, Strahinja