The neural basis of perceived intensity in natural and artificial touch.
The neural basis of perceived intensity in natural and artificial touch.
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DOI：
10.1126/scitranslmed.aaf5187
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发表时间：
2016-10-26
影响因子：
17.1
通讯作者：
Tyler DJ
中科院分区：
文献类型：
--
作者：
Graczyk EL;Schiefer MA;Saal HP;Delhaye BP;Bensmaia SJ;Tyler DJ
感觉神经的电刺激是研究神经编码的有力工具，因为它可以以自然刺激所不能的方式激活神经群。神经电刺激也被用来恢复失去肢体的病人的感觉。我们已经使用了长期植入的电接口来阐明触觉感知强度的神经基础。为此，我们通过改变神经刺激的两个参数：脉冲频率和脉冲宽度，独立地评估神经放电率和神经元群体募集的感觉相关性。具体来说，两个截肢者，长期植入外周神经电极，执行每三个心理物理任务的强度歧视，幅度缩放，强度匹配，以响应他们的体感神经的电刺激。我们发现，刺激脉冲宽度和脉冲频率有系统的，感知触觉强度的合作效果，人工触觉可以可靠地匹配到完整的肢体上的皮肤压痕。我们确定了一个量，我们称之为激活充电率（ACR），来自刺激参数，预测在所有测试条件下的人工触觉感知的幅度。根据神经纤维募集的原理，ACR代表激活的神经群体中的总群体尖峰计数。我们的研究结果支持这一假设，即人口尖峰计数驱动的触觉感知的幅度，并表明，感官幅度可以通过改变一个单一的刺激量系统地操纵。
Electrical stimulation of sensory nerves is a powerful tool for studying neural coding because it can activate neural populations in ways that natural stimulation cannot. Electrical stimulation of the nerve has also been used to restore sensation to patients who have suffered the loss of a limb. We have used long-term implanted electrical interfaces to elucidate the neural basis of perceived intensity in the sense of touch. To this end, we assessed the sensory correlates of neural firing rate and neuronal population recruitment independently by varying two parameters of nerve stimulation: pulse frequency and pulse width. Specifically, two amputees, chronically implanted with peripheral nerve electrodes, performed each of three psychophysical tasks—intensity discrimination, magnitude scaling, and intensity matching—in response to electrical stimulation of their somatosensory nerves. We found that stimulation pulse width and pulse frequency had systematic, cooperative effects on perceived tactile intensity and that the artificial tactile sensations could be reliably matched to skin indentations on the intact limb. We identified a quantity we termed the activation charge rate (ACR), derived from stimulation parameters, that predicted the magnitude of artificial tactile percepts across all testing conditions. On the basis of principles of nerve fiber recruitment, the ACR represents the total population spike count in the activated neural population. Our findings support the hypothesis that population spike count drives the magnitude of tactile percepts and indicate that sensory magnitude can be manipulated systematically by varying a single stimulation quantity.
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影响因子：
2.5
作者：
Bensmaïa, SJ;Leung, YY;Johnson, KO
通讯作者：
Johnson, KO
影响因子：
3.2
作者：
ANANI, AB;IKEDA, K;KORNER, LM
通讯作者：
KORNER, LM
影响因子：
--
作者：
GESCHEID.GA;WRIGHT, JH
通讯作者：
WRIGHT, JH
影响因子：
2.5
作者：
Dhillon, GS;Krüger, TB;Horch, KW
通讯作者：
Horch, KW
影响因子：
2.5
作者：
Ochoa JL
通讯作者：
Ochoa JL