Racial Discrimination, Inflammation, and Chronic Illness Among African American Women at Midlife: Support for the Weathering Perspective.
Racial Discrimination, Inflammation, and Chronic Illness Among African American Women at Midlife: Support for the Weathering Perspective.
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DOI：
10.1007/s40615-020-00786-8
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发表时间：
2021-04
影响因子：
3.9
通讯作者：
Beach SRH
中科院分区：
文献类型：
--
作者：
Simons RL;Lei MK;Klopack E;Zhang Y;Gibbons FX;Beach SRH
人们普遍认为，社会经济地位是健康不平等的根本原因。然而，有证据表明，种族也是健康差异的一个根本原因。基于这一观点，Geronimus和她的同事提出了风化假说，认为美国黑人中疾病和残疾率的上升是对结构性障碍、日常轻视和其他构成黑人经历的身份威胁的生理反应。目前的研究用慢性炎症作为生物风化的指标来检验风化假说。具体来说，在考虑了社会经济地位和几个控制变量后，我们研究了持续暴露于种族歧视中预测炎症升高的程度，进而诊断出慢性疾病。采用零膨胀泊松路径模型对参与家庭和社区健康研究（FACHS）的391名非裔美国妇女的五波数据进行了检验。一个包含13个项目的指数被用来评估八年来遭受种族歧视的情况。ELISA对7种与炎症反应相关的细胞因子进行血液检测，构建炎症指数。受访者报告了他们诊断出的慢性病。与风化假说一致，持续暴露于歧视中预示着炎症，而炎症反过来又预示着慢性疾病的数量。这种间接效应在统计学上是显著的。SES预测患有慢性疾病，而各种控制没有显示出影响。研究结果支持了种族和社会地位一样是健康不平等的根本原因的观点。
It is widely accepted that SES is a fundamental cause of health inequality. There is evidence, however, that race is also a fundamental cause of disparities in health. Based on this idea, the weathering hypothesis developed by Geronimus and her colleagues views the elevated rates of illness and disability seen among Black Americans as a physiological response to the structural barriers, daily slights, and other threats to identity that comprise the Black experience. The current study tests the weathering hypothesis using chronic inflammation as an indicator of biological weathering. Specifically, we examine the extent to which persistent exposure to racial discrimination predicts elevated inflammation and, in turn, diagnosed chronic illness, after taking into account SES and several control variables. This mediation model was tested using zero-inflated Poisson path modeling with five waves of data collected from 391 African American women participating in the Family and Community Health Study (FACHS). A 13-item index was used to assess exposure to racial discrimination across eight years. ELISA blood assays of seven cytokines central to the inflammatory response were used to construct an inflammatory index. Respondents reported their diagnosed chronic diseases. Consonant with the weathering hypothesis, persistent exposure to discrimination predicted inflammation which, in turn, predicted number of chronic diseases. This indirect effect was statistically significant. SES predicted having a chronic disease and the various controls showed no effect. The findings support the idea that race, like SES, is a fundamental cause of health inequalities.
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老年黑人和白人成年人心血管危险因素发生率的种族差异。
影响因子：
6.3
作者：
Howard G;Safford MM;Moy CS;Howard VJ;Kleindorfer DO;Unverzagt FW;Soliman EZ;Flaherty ML;McClure LA;Lackland DT;Wadley VG;Pulley L;Cushman M
通讯作者：
Cushman M
DOI：
10.1016/j.ssmph.2016.02.008
发表时间：
2016-12
期刊：
SSM - population health
影响因子：
--
作者：
Geronimus AT;James SA;Destin M;Graham LA;Hatzenbuehler M;Murphy M;Pearson JA;Omari A;Thompson JP
通讯作者：
Thompson JP
影响因子：
--
作者：
Bodai, Balazs I;Nakata, Therese E;Campbell, Thomas M
通讯作者：
Campbell, Thomas M
影响因子：
7.6
作者：
Brody, Gene H.;Yu, Tianyi;Chen, Edith
通讯作者：
Chen, Edith
影响因子：
5.4
作者：
Cunningham, Timothy J.;Seeman, Teresa E.;Kawachi, Ichiro;Gortmaker, Steven L.;Jacobs, David R.;Kiefe, Catarina I.;Berkman, Lisa F.
通讯作者：
Berkman, Lisa F.