No requirement of interlukine-1 for long-term potentiation in the anterior cingulate cortex of adult mice.
No requirement of interlukine-1 for long-term potentiation in the anterior cingulate cortex of adult mice.
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成年小鼠前扣带皮层的长期增强不需要白细胞介素-1
DOI：
10.1177/1744806918765799
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发表时间：
2018-01
期刊：
影响因子：
3.3
通讯作者：
Zhuo M
中科院分区：
文献类型：
--
作者：
Lu JS;Song Q;Zhang MM;Zhuo M
背景细胞因子在病理状态下表达增强，提示它们在疾病状态的启动或维持中起重要作用。调查结果：为了确定细胞因子在慢性神经病理性疼痛中的参与，研究了结扎腓总神经小鼠中前扣带皮层神经元中细胞因子的表达。我们利用细胞因子酶联免疫吸附测定板阵列检测23种细胞因子，共8只小鼠，其中包括一名女性，并没有发现这些细胞因子之间的腓总神经模型和假手术小鼠的显着差异。TNF-α在神经病理性痛和内脏痛时前扣带回皮质的表达无明显变化，而在内脏痛时岛叶皮质的表达增强。此外，我们还发现IL-1受体拮抗剂IL-1 ra对θ爆发刺激诱导的前扣带皮层长时程增强没有影响。结论前扣带皮层神经损伤引起的慢性神经病理性疼痛与细胞因子无关。我们的研究结果表明，细胞因子可能不是一个可行的药物靶点，以治疗慢性神经病理性疼痛的前扣带皮层。
Background The enhanced expression of cytokines in the pathological states suggests that they have important roles in the initiation or maintenance of disease states. Findings: To determine the involvement of cytokines in chronic neuropathic pain, the expression of cytokines in the anterior cingulate cortex neurons in the ligation of the common peroneal nerve mice was investigated. We utilized a cytokine enzyme-linked immunosorbent assay plate array to detect 23 cytokines in total eight mice including a female, and no significant differences were found in those cytokines between the common peroneal nerve model and sham surgery mice. Quantification of TNF-α at protein level revealed the unvaried expression in the anterior cingulate cortex in both neuropathic pain and visceral pain, but enhanced expression in the insular cortex in the visceral pain. Furthermore, we found that the IL-Ira, a kind of IL-1 receptor antagonist, had no effect on the theta burst stimulation-induced long-term potentiation in the anterior cingulate cortex. Conclusions Cytokines are not involved in chronic neuropathic pain induced by nerve injury in the anterior cingulate cortex. Our findings suggested that cytokines may not be a viable drug target to treat chronic neuropathic pain in the anterior cingulate cortex.
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影响因子：
2.7
作者：
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