High-density lipoprotein cholesterol to low-density lipoprotein cholesterol ratio in early assessment of disease severity and outcome in patients with acute pancreatitis admitted to the ICU
High-density lipoprotein cholesterol to low-density lipoprotein cholesterol ratio in early assessment of disease severity and outcome in patients with acute pancreatitis admitted to the ICU
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高密度脂蛋白胆固醇与低密度脂蛋白胆固醇比值对入住 ICU 的急性胰腺炎患者疾病严重程度和结局的早期评估
DOI：
10.1186/s12876-020-01315-x
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发表时间：
2020-05
影响因子：
2.4
通讯作者：
Kang Yan
中科院分区：
文献类型：
--
作者：
Wu Qin;Zhong Xi;Fu Min;Yang Hao;Bo Hong;Liao Xuelian;Hu Zhi;Wang Bo;Zhang Zhongwei;Jin Xiaodong;Kang Yan
研究背景急性胰腺炎患者常伴有血脂异常和氧化应激。但高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）及HDL-C/LDL-C比值的意义高密度脂蛋白胆固醇（HDL-C）水平与高密度脂蛋白胆固醇（H/L）比值的相关性尚不清楚，LDL-C水平和H/L比值作为急性胰腺炎重症监护病房患者疾病进展的标志。在中国的一家三级重症监护中心进行。本文测定了166例急性胰腺炎患者血浆HDL-C和LDL-C水平。分析高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（H/L）比值及其他炎症指标与死亡率的关系。基于两个模型的多因素考克斯分析用于确定独立的预后因素。预测能力的住院死亡率的变量被确定为使用接收器的操作特性currents.ResultsSignificantly较高的H/L比值在入院时观察到急性胰腺炎患者死亡的幸存者相比（0.93与0.64，P<0.001）。基于H/L比值预测死亡率的ROC曲线下面积为0.658。当临床混杂因素纳入多变量考克斯回归分析时，相关性得以保留（模型A HR=1.587，p=0.011;模型B HR=1.332，p=0.032）。在不同组的H/L比截止值定义的死亡风险是显着不同的，生存曲线analysis.ConclusionThe H/L比入院时的ICU似乎是急性胰腺炎患者的疾病进展的生物标志物。
BackgroundPatients with acute pancreatitis usually exhibit dyslipidemia and oxidative stress. However, the significance of high-density lipoprotein cholesterol (HDL-C) level, low-density lipoprotein cholesterol (LDL-C) level and the HDL-C/LDL-C ratio (H/L ratio) as markers for disease progression remain unknown.AimThe aim of this study was to evaluate the role of HDL-C levels, LDL-C levels and the H/L ratio as markers of disease progression in patients admitted to the intensive cate unit with acute pancreatitis.MethodsThis retrospective study was conducted at a tertiary critical care center in China. Plasma HDL-C and LDL-C levels were measured in 166 patients with acute pancreatitis. The associations between HDL-C, LDL-C, H/L ratio, as well as other inflammatory index and mortality, were analyzed. Multivariate cox analysis based on two models was used to determine the independent prognostic factor. Predictive ability of in-hospital mortality for variables was determined using the receiver operating characteristics curves.ResultsSignificantly higher H/L ratios at admission were observed in patients with acute pancreatitis who died compared with survivors (0.93 vs. 0.64, p<0.001). The area under the ROC curve for H/L ratio-based prediction of mortality was 0.658. When clinical confounders were included in multivariable cox regression analysis, the association was preserved (Model A HR=1.587, p=0.011; Model B HR=1.332, p=0.032). The mortality risk in different groups defined by an H/L ratio cutoff value was significantly different, based on survival curve analysis.ConclusionThe H/L ratio at the time of admission to the ICU appears to be a biomarker of disease progression in patients with acute pancreatitis.
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DOI：
10.1007/978-3-030-26710-0_69
发表时间：
2020
期刊：
Evidence-Based Critical Care
影响因子：
--
作者：
M. Ragland;C. Weiss
通讯作者：
M. Ragland;C. Weiss
影响因子：
--
作者：
Ye-Liu Liu-Ye-Liu-Liu-2108335677;H. Qian;L. Qin;Xiao-jun Zhou;Bo Zhang
通讯作者：
Ye-Liu Liu-Ye-Liu-Liu-2108335677;H. Qian;L. Qin;Xiao-jun Zhou;Bo Zhang
影响因子：
2.3
作者：
Klöppel, G
通讯作者：
Klöppel, G
影响因子：
6
作者：
Ikeura, Tsukasa;Horibe, Masayasu;Mayumi, Toshihiko
通讯作者：
Mayumi, Toshihiko
DOI：
10.1002/9781119570097.ch1
发表时间：
2021-06
期刊：
--
影响因子：
--
作者：
J. Barkin;J. Barkin
通讯作者：
J. Barkin;J. Barkin