Moving beyond static snapshots: Protein dynamics and the Protein Data Bank.
Moving beyond static snapshots: Protein dynamics and the Protein Data Bank.
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DOI：
10.1016/j.jbc.2021.100749
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Phillips GN Jr
中科院分区：
文献类型：
--
作者：
Miller MD;Phillips GN Jr
蛋白质是生命系统的分子机器。它们的动态是它们执行生物功能的进化选择的内在组成部分。尽管动态比静态的、平均的结构更难观察，但我们开始观察这些动态，并在结构、动态和功能之间形成良好的机械联系。这一进展在从肌红蛋白和腺苷酸激酶到核糖体和分子马达的案例研究中得到了突出的体现，在这些研究中，这些分子正在用多种技术在许多时间尺度上进行探测。时间分辨结晶学的新方法使人们能够简单地拍摄起作用的蛋白质的“电影”，而绘制低温电子显微镜变异图的新方法正在出现，以揭示对生命机器的更完整的描述。蛋白质数据库及其在世界各地的合作伙伴在管理和分发方面的持续改进有助于这些新方法的结果的传播。
Proteins are the molecular machines of living systems. Their dynamics are an intrinsic part of their evolutionary selection in carrying out their biological functions. Although the dynamics are more difficult to observe than a static, average structure, we are beginning to observe these dynamics and form sound mechanistic connections between structure, dynamics, and function. This progress is highlighted in case studies from myoglobin and adenylate kinase to the ribosome and molecular motors where these molecules are being probed with a multitude of techniques across many timescales. New approaches to time-resolved crystallography are allowing simple “movies” to be taken of proteins in action, and new methods of mapping the variations in cryo-electron microscopy are emerging to reveal a more complete description of life’s machines. The results of these new methods are aided in their dissemination by continual improvements in curation and distribution by the Protein Data Bank and their partners around the world.
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影响因子：
3.9
作者：
Assalauova D;Kim YY;Bobkov S;Khubbutdinov R;Rose M;Alvarez R;Andreasson J;Balaur E;Contreras A;DeMirci H;Gelisio L;Hajdu J;Hunter MS;Kurta RP;Li H;McFadden M;Nazari R;Schwander P;Teslyuk A;Walter P;Xavier PL;Yoon CH;Zaare S;Ilyin VA;Kirian RA;Hogue BG;Aquila A;Vartanyants IA
通讯作者：
Vartanyants IA
影响因子：
2.9
作者：
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通讯作者：
Phillips, GN
影响因子：
15
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通讯作者：
Agarwal, PK
影响因子：
56.9
作者：
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通讯作者：
Schlichting, Ilme
影响因子：
64.8
作者：
Chapman, Henry N.;Fromme, Petra;Barty, Anton;White, Thomas A.;Kirian, Richard A.;Aquila, Andrew;Hunter, Mark S.;Schulz, Joachim;DePonte, Daniel P.;Weierstall, Uwe;Doak, R. Bruce;Maia, Filipe R. N. C.;Martin, Andrew V.;Schlichting, Ilme;Lomb, Lukas;Coppola, Nicola;Shoeman, Robert L.;Epp, Sascha W.;Hartmann, Robert;Rolles, Daniel;Rudenko, Artem;Foucar, Lutz;Kimmel, Nils;Weidenspointner, Georg;Holl, Peter;Liang, Mengning;Barthelmess, Miriam;Caleman, Carl;Boutet, Sebastien;Bogan, Michael J.;Krzywinski, Jacek;Bostedt, Christoph;Bajt, Sasa;Gumprecht, Lars;Rudek, Benedikt;Erk, Benjamin;Schmidt, Carlo;Hoemke, Andre;Reich, Christian;Pietschner, Daniel;Strueder, Lothar;Hauser, Guenter;Gorke, Hubert;Ullrich, Joachim;Herrmann, Sven;Schaller, Gerhard;Schopper, Florian;Soltau, Heike;Kuehnel, Kai-Uwe;Messerschmidt, Marc;Bozek, John D.;Hau-Riege, Stefan P.;Frank, Matthias;Hampton, Christina Y.;Sierra, Raymond G.;Starodub, Dmitri;Williams, Garth J.;Hajdu, Janos;Timneanu, Nicusor;Seibert, M. Marvin;Andreasson, Jakob;Rocker, Andrea;Joensson, Olof;Svenda, Martin;Stern, Stephan;Nass, Karol;Andritschke, Robert;Schroeter, Claus-Dieter;Krasniqi, Faton;Bott, Mario;Schmidt, Kevin E.;Wang, Xiaoyu;Grotjohann, Ingo;Holton, James M.;Barends, Thomas R. M.;Neutze, Richard;Marchesini, Stefano;Fromme, Raimund;Schorb, Sebastian;Rupp, Daniela;Adolph, Marcus;Gorkhover, Tais;Andersson, Inger;Hirsemann, Helmut;Potdevin, Guillaume;Graafsma, Heinz;Nilsson, Bjoern;Spence, John C. H.
通讯作者：
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