The apolipoprotein E content of HDL in cerebrospinal fluid is higher in children than in adults.
The apolipoprotein E content of HDL in cerebrospinal fluid is higher in children than in adults.
复制标题
儿童脑脊液中HDL载脂蛋白E含量高于成人。
DOI：
10.1093/clinchem/45.8.1294
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发表时间：
1999
影响因子：
9.3
通讯作者：
M. Okada
中科院分区：
文献类型：
--
作者：
T. Miida;F. Yamazaki;Miho Sakurai;Reiko Wada;Toru Yamadera;K. Asami;M. Hoshiyama;A. Tanaka;K. Inano;M. Okada
血脑屏障使脑脊液（CSF）中的蛋白质浓度远低于血清（1）（2）（3）（4）。然而，CSF载脂蛋白E（apoE）浓度约为血清apoE浓度的十分之一到二十分之一（5）（6）（7）（8）（9）（10）（11）（12）（13）。主要是神经胶质细胞在中枢神经系统中分泌apoE（14）（15）（16）。CSF apoE仅由HDL携带，HDL是CSF中的主要脂蛋白（17）（18）。CSF apoE浓度在神经系统疾病如中枢神经系统炎性疾病（5）（19）和阿尔茨海默病（7）（8）（9）（10）（11）（12）（13）中变化。然而，脑脊液apoE浓度的临床意义尚不清楚。
最近的研究表明，CSF HDL的apoE含量比CSF apoE浓度更重要（20）。富含apoE的HDL促进神经生长因子诱导的神经突生长（20）。由于突触数量在儿童期显著增加（21），因此儿童CSF HDL的apoE含量可能高于成人。为了解决这个问题，我们同时测量了脑脊液中的apoE和磷脂（PL）浓度。
从59名神经系统正常的受试者（42名男性和17名女性，年龄2-86岁）获得样品。59例受试者中，30例为急性白血病完全缓解期患者，其余为手术治疗患者。
The blood-brain barrier keeps the protein concentrations in cerebrospinal fluid (CSF) much lower than in serum (1)(2)(3)(4). However, the CSF apolipoprotein E (apoE) concentration is approximately one-tenth to one-twentieth of the serum apoE concentration (5)(6)(7)(8)(9)(10)(11)(12)(13). Mainly glia cells secrete apoE in the central nervous system (14)(15)(16). CSF apoE is carried exclusively on HDL, which is the major lipoprotein in the CSF (17)(18). The CSF apoE concentration varies in neurological disorders such as central nervous system inflammatory diseases (5)(19) and Alzheimer disease (7)(8)(9)(10)(11)(12)(13). However, the clinical significance of the CSF apoE concentration is still unclear.
Recent studies have suggested that the apoE content of CSF HDL is more important than the CSF apoE concentration (20). HDL enriched with apoE promotes nerve growth factor-induced neurite outgrowth (20). Because the number of synapses increases markedly in childhood (21), the apoE content of CSF HDL might be higher in children than in adults. To address this question, we measured the apoE and phospholipid (PL) concentrations in CSF simultaneously.
Samples were obtained from 59 neurologically normal subjects (42 males and 17 females, ages 2–86 years). Of the 59 subjects, 30 were patients with acute leukemia in complete remission, the others were patients who underwent surgery …
DOI：
--
发表时间：
1991-06
期刊：
The American journal of pathology
影响因子：
--
作者：
Tzyy Choou Wu;Risa B. Mann;Jonathan I. Epstein;E. Macmahon;W. Lee;Patricia Charache;S. Hayward;Robert J. Kurman;Gary S. Hayward;R. Ambinder
通讯作者：
Tzyy Choou Wu;Risa B. Mann;Jonathan I. Epstein;E. Macmahon;W. Lee;Patricia Charache;S. Hayward;Robert J. Kurman;Gary S. Hayward;R. Ambinder
前β-迁移高密度脂蛋白：电泳转移后通过固相放射免疫测定对正常和高脂血症血浆进行定量。
影响因子：
6.5
作者：
Ishida,BY;Frolich,J;Fielding,CJ
通讯作者：
Fielding,CJ
使用 DNA 扩增方法进行自身免疫性疾病的临床诊断。
影响因子：
2.7
作者：
Fox,RI;Dotan,I;Compton,T;Fei,HM;Hamer,M;Saito,I
通讯作者：
Saito,I