Very high mutation rate in offspring of Chernobyl accident liquidators
Very high mutation rate in offspring of Chernobyl accident liquidators
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切尔诺贝利事故清理者后代的突变率非常高
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
E. Skvarskaja
中科院分区：
文献类型：
--
作者：
H. M. Sh;Abraham B. Korol;V. Kirzhner;Aaron Avivi;T. Fahima;Eviatar Nevo;Stuart C. Shapiro;Gad Rennert;O. Piatak;E. Stepanova;E. Skvarskaja
长期以来，人们一直怀疑暴露在电离辐射中会增加人类的突变负荷。然而，像原子弹爆炸这样的事件似乎并没有产生重大的基因缺陷。切尔诺贝利事故造成了不同的、长期的辐射暴露。切尔诺贝利反应堆的清理小组(或“清算员”)是受到最高剂量的人之一，估计是急性和慢性形式的某种组合。在这项研究中，使用多点DNA指纹技术对父母暴露于(CA)辐射后出生的清算家庭(目前在乌克兰或以色列)出生的孩子进行了新片段的筛查。他们在接触(CB)前孕育的兄弟姐妹除了作为外部对照(非暴露家庭)外，还充当关键的内部控制。与对照组相比，CA患者的新条带数量意外增加(7倍)。在乌克兰家庭中，随着暴露到后代受孕之间的时间推移，新带子的数量有明显减少的趋势。这些结果表明，低剂量辐射可引起人类生殖系DNA的多种改变。
Exposure to ionizing radiation has long been suspected to increase mutation load in humans. Nevertheless, such events as atomic bombing seem not to have yielded significant genetic defects. The Chernobyl accident created a different, long–term exposure to radiation. Clean–up teams (or 'liquidators') of the Chernobyl reactor are among those who received the highest doses, presumably in some combination of acute and chronic forms. In this study, children born to liquidator families (currently either in the Ukraine or Israel) conceived after (CA) parental exposure to radiation were screened for the appearance of new fragments using multi–site DNA fingerprinting. Their sibs conceived before (CB) exposure served as critical internal controls, in addition to external controls (non–exposed families). An unexpectedly high (sevenfold) increase in the number of new bands in CA individuals compared with the level seen in controls was recorded. A strong tendency for the number of new bands to decrease with elapsed time between exposure and offspring conception was established for the Ukrainian families. These results indicate that low doses of radiation can induce multiple changes in human germline DNA.
人类和小鼠的比较辐射遗传学。
影响因子：
11.1
作者：
Neel,JV;Lewis,SE
通讯作者：
Lewis,SE
RAPD/AP-PCR 检测实验动物和人类癌症组织基因组中的突变或多态位点依赖于 DNA 聚合酶。
影响因子：
5.2
作者：
Singh,KP;Roy,D
通讯作者：
Roy,D
原子弹伤亡委员会-辐射效应研究基金会的基因研究：1946-1997。
DOI：
10.1073/pnas.95.10.5432
发表时间：
1998
影响因子：
11.1
作者：
Neel,JV
通讯作者：
Neel,JV