Microstructural alterations in association tracts and language abilities in schoolchildren born very preterm and with poor fetal growth.
Microstructural alterations in association tracts and language abilities in schoolchildren born very preterm and with poor fetal growth.
复制标题
DOI：
10.1007/s00247-022-05418-3
复制
发表时间：
2023-01
影响因子：
2.3
通讯作者：
Kaukola, Tuula
中科院分区：
文献类型：
--
作者：
Kallankari, Hanna;Taskila, Hanna-Leena;Heikkinen, Minna;Hallman, Mikko;Saunavaara, Virva;Kaukola, Tuula
关键词：
早产和围产期危险因素可能会影响白色物质的微观结构。反过来，这些成熟的变化可能会影响语言的发展，在这个高风险的儿童群体。评估早产儿和足月儿之间以及正常生长的早产儿和胎儿生长受限的早产儿之间的联合束微观结构差异，并研究这些束的弥散张量指标是否与无严重神经功能障碍的学龄儿童的语言能力相关。本研究前瞻性随访了56名极早产儿（平均胎龄：28.7周）和21名年龄和性别匹配的足月儿，他们在平均9岁时接受了弥散张量成像。我们使用了自动概率纤维束成像，并测量了已知属于白色物质语言网络的七个双边联合束的分数各向异性。两组学生在相同的年龄参加了五次标准化测试的语言评估。早产儿右侧上级纵束1的各向异性分数低于足月儿（P < 0.05）。胎儿生长受限的早产儿左下纵束各向异性分数低于胎儿生长正常的早产儿（P < 0.05）。早产儿和胎儿生长受限早产儿的三条背侧束和两条背侧束和一条腹侧束的各向异性分数分别与语言评估呈正相关（P < 0.05）。早产儿和足月儿之间以及胎儿生长发育正常的早产儿和胎儿生长发育受限的早产儿之间的语言相关神经束存在一些微结构差异。语言能力较好的儿童在不同的白色物质束中具有较高的分数各向异性。
Prematurity and perinatal risk factors may influence white matter microstructure. In turn, these maturational changes may influence language development in this high-risk population of children. To evaluate differences in the microstructure of association tracts between preterm and term children and between preterm children with appropriate growth and those with fetal growth restriction and to study whether the diffusion tensor metrics of these tracts correlate with language abilities in schoolchildren with no severe neurological impairment. This study prospectively followed 56 very preterm children (mean gestational age: 28.7 weeks) and 21 age- and gender-matched term children who underwent diffusion tensor imaging at a mean age of 9 years. We used automated probabilistic tractography and measured fractional anisotropy in seven bilateral association tracts known to belong to the white matter language network. Both groups participated in language assessment using five standardised tests at the same age. Preterm children had lower fractional anisotropy in the right superior longitudinal fasciculus 1 compared to term children (P < 0.05). Preterm children with fetal growth restriction had lower fractional anisotropy in the left inferior longitudinal fasciculus compared to preterm children with appropriate fetal growth (P < 0.05). Fractional anisotropy in three dorsal tracts and in two dorsal and one ventral tract had a positive correlation with language assessments among preterm children and preterm children with fetal growth restriction, respectively (P < 0.05). There were some microstructural differences in language-related tracts between preterm and term children and between preterm children with appropriate and those with restricted fetal growth. Children with better language abilities had a higher fractional anisotropy in distinct white matter tracts.
登录
查看更多内容
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
2.9
作者：
Padilla, Nelly;Junque, Carme;Gratacos, Eduard
通讯作者：
Gratacos, Eduard
影响因子：
2.7
作者：
DEVRIES, LS;EKEN, P;DUBOWITZ, LMS
通讯作者：
DUBOWITZ, LMS
影响因子：
14.5
作者：
DERENZI, E;VIGNOLO, LA
通讯作者：
VIGNOLO, LA
影响因子：
3.8
作者：
Kallankari, Hanna;Kaukola, Tuula;Hallman, Mikko
通讯作者：
Hallman, Mikko