It takes a village: Phagocytes play a central role in fungal immunity.
It takes a village: Phagocytes play a central role in fungal immunity.
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DOI：
10.1016/j.semcdb.2018.04.008
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发表时间：
2019-05
影响因子：
7.3
通讯作者：
Mansour MK
中科院分区：
文献类型：
--
作者：
Feldman MB;Vyas JM;Mansour MK
吞噬作用是先天免疫应答侵袭性真菌感染的重要步骤。这个过程是由众所周知的专业吞噬细胞“村庄”完成的，它们已经进化出有效的机制来识别和吞噬病原体，即巨噬细胞、中性粒细胞和树突状细胞。这些先天免疫细胞驱动早期细胞因子的产生、杀真菌活性、抗原呈递和适应性免疫系统的激活。尽管开发了具有有效活性的抗真菌药物，但事实证明，专业吞噬性先天免疫细胞的生物活性在保护宿主免受侵袭性真菌感染方面是不可或缺的。此外，越来越多的证据表明，非专业吞噬细胞，如气道上皮细胞，进行吞噬，并可能在消除真菌病原体中发挥关键作用。在这里，我们回顾了专业和非专业吞噬细胞对真菌病原体的吞噬反应的最新进展，重点是侵袭性曲霉病作为一种模式疾病。
Phagocytosis is an essential step in the innate immune response to invasive fungal infections. This process is carried out by a proverbial “village” of professional phagocytic cells, which have evolved efficient machinery to recognize and ingest pathogens, namely macrophages, neutrophils and dendritic cells. These innate immune cells drive early cytokine production, fungicidal activity, antigen presentation and activation of the adaptive immune system. Despite the development of antifungal agents with potent activity, the biological activity of professional phagocytic innate immune cells has proven indispensable in protecting a host from invasive fungal infections. Additionally, an emerging body of evidence suggests non-professional phagocytes, such as airway epithelial cells, carry out phagocytosis and may play a critical role in the elimination of fungal pathogens. Here, we review recent advances of phagocytosis by both professional and non-professional phagocytes in response to fungal pathogens, with a focus on invasive aspergillosis as a model disease.
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